Comparison of the offspring of three serial pregnancies during voluntary alcohol consumption in Sinclair (S-1) miniature swine

J. D. Dexter, M. E. Tumbleson, J. D. Decker, C. Middleton c.

Research output: Contribution to journalArticlepeer-review

Abstract

The offspring of serial breedings of voluntary alcohol consuming Sinclair (S-1) miniature swine have been evaluated over the past three years. The first and second litters of 12 dams and the third litter of 6 dams were examined. All study animals had been consuming alcohol for at least 18 months prior to the first breeding. Alcohol consumption was continuous throughout the ninth study. Twelve non-alcohol-consuming sows were used as controls. The results of the study revealed a progressive decrease in mean litter size from controls of 6.66 in the control litters to 1.8 piglets per litter in the third litter born to alchol-consuming dams. Perinatal deaths showed a progressive increase form 10% in the control to 36.4% in the L3 litter. The birth weight showed a decline from a mean of 710±186 g in the control group to 467±122 g in the L3 litter. Abortions were not seen in control, first litter or second litter; however, there were 3 aborted fetuses in the third litter. Observation revealed no additional anomalies beyond the previous reports of anomalies seen in litters of alcohol-consuming S-1 miniature swine dams.

Original languageEnglish (US)
Pages (from-to)229-231
Number of pages3
JournalNeurobehavioral Toxicology and Teratology
Volume5
Issue number2
StatePublished - Jan 1 1983
Externally publishedYes

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Embryology
  • Toxicology

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