Eight pairs of 0-methyl and 0-ethyl 0-(substituted-phenyl) phenylphosphonothionates were evaluated with respect to their delayed neurotoxic activity in hens. 0-methyl compounds were in all cases more active than their 0-ethyl analogs. The neurotoxic potential of the 0-methyl phenylphosphonothionates was 2,5-diCl >4-NQ2 >2,4,5-triCl and 2,4,6-triCl >2,4-diCl >2,5~diCl-4-Br >4-CN, when single oral doses were given. Both EPN-ethyl and leptophos-methyl were more neurotoxic in multiple dermal than multiple oral dosing regimens. LD50s for mice and flies were established.
|Original language||English (US)|
|Number of pages||23|
|Journal||Journal of Environmental Science and Health, Part B|
|State||Published - Jan 1 1982|
- organophosphorus ester induced delayed neurotoxicity
ASJC Scopus subject areas
- Food Science