Comparison of the delayed neurotoxicity of 0 -methyl and 0-ethyl analogs of epn, leptophos, and cyanofenphos

B. Magnus Francis, Larry G. Hansen, Robert A. Metcalf, Robert L. Metcalf

Research output: Contribution to journalArticle

Abstract

Eight pairs of 0-methyl and 0-ethyl 0-(substituted-phenyl) phenylphosphonothionates were evaluated with respect to their delayed neurotoxic activity in hens. 0-methyl compounds were in all cases more active than their 0-ethyl analogs. The neurotoxic potential of the 0-methyl phenylphosphonothionates was 2,5-diCl >4-NQ2 >2,4,5-triCl and 2,4,6-triCl >2,4-diCl >2,5~diCl-4-Br >4-CN, when single oral doses were given. Both EPN-ethyl and leptophos-methyl were more neurotoxic in multiple dermal than multiple oral dosing regimens. LD50s for mice and flies were established.

Original languageEnglish (US)
Pages (from-to)611-633
Number of pages23
JournalJournal of Environmental Science and Health, Part B
Volume17
Issue number6
DOIs
StatePublished - Jan 1 1982

Keywords

  • organophosphorus ester induced delayed neurotoxicity

ASJC Scopus subject areas

  • Food Science
  • Pollution

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