TY - JOUR
T1 - Comparison of the delayed neurotoxicity of 0 -methyl and 0-ethyl analogs of epn, leptophos, and cyanofenphos
AU - Francis, B. Magnus
AU - Hansen, Larry G.
AU - Metcalf, Robert A.
AU - Metcalf, Robert L.
PY - 1982/1/1
Y1 - 1982/1/1
N2 - Eight pairs of 0-methyl and 0-ethyl 0-(substituted-phenyl) phenylphosphonothionates were evaluated with respect to their delayed neurotoxic activity in hens. 0-methyl compounds were in all cases more active than their 0-ethyl analogs. The neurotoxic potential of the 0-methyl phenylphosphonothionates was 2,5-diCl >4-NQ2 >2,4,5-triCl and 2,4,6-triCl >2,4-diCl >2,5~diCl-4-Br >4-CN, when single oral doses were given. Both EPN-ethyl and leptophos-methyl were more neurotoxic in multiple dermal than multiple oral dosing regimens. LD50s for mice and flies were established.
AB - Eight pairs of 0-methyl and 0-ethyl 0-(substituted-phenyl) phenylphosphonothionates were evaluated with respect to their delayed neurotoxic activity in hens. 0-methyl compounds were in all cases more active than their 0-ethyl analogs. The neurotoxic potential of the 0-methyl phenylphosphonothionates was 2,5-diCl >4-NQ2 >2,4,5-triCl and 2,4,6-triCl >2,4-diCl >2,5~diCl-4-Br >4-CN, when single oral doses were given. Both EPN-ethyl and leptophos-methyl were more neurotoxic in multiple dermal than multiple oral dosing regimens. LD50s for mice and flies were established.
KW - organophosphorus ester induced delayed neurotoxicity
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U2 - 10.1080/03601238209372346
DO - 10.1080/03601238209372346
M3 - Article
C2 - 7166625
AN - SCOPUS:0020258908
SN - 0360-1234
VL - 17
SP - 611
EP - 633
JO - Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes
JF - Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes
IS - 6
ER -