Comparison of neuronal and hemodynamic measures of the brain response to visual stimulation: An optical imaging study

Gabriele Gratton, Marsha Ruth Goodman-Wood, Monica Fabiani

Research output: Contribution to journalArticle

Abstract

The noninvasive mapping of hemodynamic brain activity has led to significant advances in neuroimaging. This approach is based in part on the assumption that hemodynamic changes are proportional to (and therefore constitute a linear measure of) neuronal activity. We report a study investigating the quantitative relationship between neuronal and hemodynamic measures, This study exploited the fact that optical imaging methods can simultaneously provide noninvasive measures of neuronal and hemodynamic activity from the same region of the brain. We manipulated visual stimulation frequency and measured responses from the medial occipital area of 8 young adults. The results were consistent with a model postulating a linear relationship between the neuronal activity integrated over time and the amplitude of the hemodynamic response. The hemodynamic response colocalized with the neuronal response. These data support the use of quantitative neuroimaging methods to infer the intensity and localization of neuronal activity in occipital areas.

Original languageEnglish (US)
Pages (from-to)13-25
Number of pages13
JournalHuman Brain Mapping
Volume13
Issue number1
DOIs
StatePublished - Mar 2 2001

Keywords

  • Event-related optical signal (EROS)
  • Hemodynamic measures
  • Near-infrared spectroscopy (NIRS)
  • Neuronal measures
  • Neurovascular coupling

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

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