Comparison of animal models for the evaluation of radiolabeled androgens

Joanna B. Downer; Lynne A. Jones; John A. Engelbach; Lennis L. Lich; Wang Mao; Kathryn E. Carlson; John A. Katzenellenbogen; Michael J. Welch

doi:10.1016/S0969-8051(01)00229-3

Comparison of animal models for the evaluation of radiolabeled androgens

Joanna B. Downer, Lynne A. Jones, John A. Engelbach, Lennis L. Lich, Wang Mao, Kathryn E. Carlson, John A. Katzenellenbogen, Michael J. Welch

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Biodistribution of two ¹⁸F-labeled androgens and an ¹²⁴I/¹²⁵I-labeled androgen were studied in five androgen receptor (prostate) animal models with or lacking sex hormone binding globulin (SHBG). As models for androgen-receptor positive ovarian cancer, xenografts of three human ovarian cancer cell lines were tested in SCID mice. SHBG in the prostate model systems significantly affects the metabolism, clearance, and distribution of the radiolabeled androgens in several tissues, but ovarian cancer animal models were disappointing.

Original language	English (US)
Pages (from-to)	613-626
Number of pages	14
Journal	Nuclear Medicine and Biology
Volume	28
Issue number	6
DOIs	https://doi.org/10.1016/S0969-8051(01)00229-3
State	Published - 2001

Keywords

Androgens
Animal models
Ovarian cancer
Positron emission tomography
Sex hormone binding globulin

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging
Cancer Research

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10.1016/S0969-8051(01)00229-3

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title = "Comparison of animal models for the evaluation of radiolabeled androgens",

abstract = "Biodistribution of two 18F-labeled androgens and an 124I/125I-labeled androgen were studied in five androgen receptor (prostate) animal models with or lacking sex hormone binding globulin (SHBG). As models for androgen-receptor positive ovarian cancer, xenografts of three human ovarian cancer cell lines were tested in SCID mice. SHBG in the prostate model systems significantly affects the metabolism, clearance, and distribution of the radiolabeled androgens in several tissues, but ovarian cancer animal models were disappointing.",

keywords = "Androgens, Animal models, Ovarian cancer, Positron emission tomography, Sex hormone binding globulin",

author = "Downer, {Joanna B.} and Jones, {Lynne A.} and Engelbach, {John A.} and Lich, {Lennis L.} and Wang Mao and Carlson, {Kathryn E.} and Katzenellenbogen, {John A.} and Welch, {Michael J.}",

note = "Funding Information: The authors acknowledge the following sources of funding: U.S. Department of Energy [DE-FG02-84ER60218 (MJW) and DE-FG02-86ER 60401 (JAK)] and National Institutes of Health [P01 HL13851 (MJW) and R01 CA25836 (JAK)]. In addition, special thanks to Pilar Herrero, Glenn Foster, Elizabeth Sherman, Margaret Morris, Terry Sharp and Jian Wang of Washington University School of Medicine, and Karen Kirschbaum of the University of Illinois Urbana-Champaign. ",

year = "2001",

doi = "10.1016/S0969-8051(01)00229-3",

language = "English (US)",

volume = "28",

pages = "613--626",

journal = "Nuclear Medicine and Biology",

issn = "0969-8051",

publisher = "Elsevier Inc.",

number = "6",

}

TY - JOUR

T1 - Comparison of animal models for the evaluation of radiolabeled androgens

AU - Downer, Joanna B.

AU - Jones, Lynne A.

AU - Engelbach, John A.

AU - Lich, Lennis L.

AU - Mao, Wang

AU - Carlson, Kathryn E.

AU - Katzenellenbogen, John A.

AU - Welch, Michael J.

N1 - Funding Information: The authors acknowledge the following sources of funding: U.S. Department of Energy [DE-FG02-84ER60218 (MJW) and DE-FG02-86ER 60401 (JAK)] and National Institutes of Health [P01 HL13851 (MJW) and R01 CA25836 (JAK)]. In addition, special thanks to Pilar Herrero, Glenn Foster, Elizabeth Sherman, Margaret Morris, Terry Sharp and Jian Wang of Washington University School of Medicine, and Karen Kirschbaum of the University of Illinois Urbana-Champaign.

PY - 2001

Y1 - 2001

N2 - Biodistribution of two 18F-labeled androgens and an 124I/125I-labeled androgen were studied in five androgen receptor (prostate) animal models with or lacking sex hormone binding globulin (SHBG). As models for androgen-receptor positive ovarian cancer, xenografts of three human ovarian cancer cell lines were tested in SCID mice. SHBG in the prostate model systems significantly affects the metabolism, clearance, and distribution of the radiolabeled androgens in several tissues, but ovarian cancer animal models were disappointing.

AB - Biodistribution of two 18F-labeled androgens and an 124I/125I-labeled androgen were studied in five androgen receptor (prostate) animal models with or lacking sex hormone binding globulin (SHBG). As models for androgen-receptor positive ovarian cancer, xenografts of three human ovarian cancer cell lines were tested in SCID mice. SHBG in the prostate model systems significantly affects the metabolism, clearance, and distribution of the radiolabeled androgens in several tissues, but ovarian cancer animal models were disappointing.

KW - Androgens

KW - Animal models

KW - Ovarian cancer

KW - Positron emission tomography

KW - Sex hormone binding globulin

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U2 - 10.1016/S0969-8051(01)00229-3

DO - 10.1016/S0969-8051(01)00229-3

M3 - Article

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AN - SCOPUS:0034881910

SN - 0969-8051

VL - 28

SP - 613

EP - 626

JO - Nuclear Medicine and Biology

JF - Nuclear Medicine and Biology

IS - 6

ER -

Comparison of animal models for the evaluation of radiolabeled androgens

Abstract

Keywords

ASJC Scopus subject areas

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