Comparison of animal models for the evaluation of radiolabeled androgens

Joanna B. Downer, Lynne A. Jones, John A. Engelbach, Lennis L. Lich, Wang Mao, Kathryn E. Carlson, John A. Katzenellenbogen, Michael J. Welch

Research output: Contribution to journalArticlepeer-review


Biodistribution of two 18F-labeled androgens and an 124I/125I-labeled androgen were studied in five androgen receptor (prostate) animal models with or lacking sex hormone binding globulin (SHBG). As models for androgen-receptor positive ovarian cancer, xenografts of three human ovarian cancer cell lines were tested in SCID mice. SHBG in the prostate model systems significantly affects the metabolism, clearance, and distribution of the radiolabeled androgens in several tissues, but ovarian cancer animal models were disappointing.

Original languageEnglish (US)
Pages (from-to)613-626
Number of pages14
JournalNuclear Medicine and Biology
Issue number6
StatePublished - 2001


  • Androgens
  • Animal models
  • Ovarian cancer
  • Positron emission tomography
  • Sex hormone binding globulin

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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