Comparative mammalian cell toxicity of N-DBPs and C-DBPs

Michael Jacob Plewa, Elizabeth D. Wagner, Mark G. Muellner, Kang Mei Hsu, Susan D. Richardson

Research output: Chapter in Book/Report/Conference proceedingConference contribution


In order to generate a quantitative, direct comparison amongst classes of drinking water disinfection by-products (DBPs), we developed and calibrated in vitro mammalian cell cytotoxicity and genotoxicity assays to integrate the analytical biology with the analytical chemistry of these important environmental contaminants. The generated database demonstrates the universality of the comparative toxicity of iodo- > bromo- >> chloro-DBPs across different structural DBP classes and the substantially greater toxicity of nitrogen-containing DBPs (N- DBPs) compared to carbonaceous DBPs (C-DBPs). These results are important in light of the generation of iodinated- DBPs and N-DBPs that may result from the use of alternative disinfectants.

Original languageEnglish (US)
Title of host publicationDisinfection By-Products in Drinking Water
Subtitle of host publicationOccurrence, Formation, Health Effects, and Control
PublisherAmerican Chemical Society
Number of pages15
ISBN (Print)9780841269507
StatePublished - Aug 5 2008

Publication series

NameACS Symposium Series
ISSN (Print)0097-6156
ISSN (Electronic)1947-5918

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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  • Cite this

    Plewa, M. J., Wagner, E. D., Muellner, M. G., Hsu, K. M., & Richardson, S. D. (2008). Comparative mammalian cell toxicity of N-DBPs and C-DBPs. In Disinfection By-Products in Drinking Water: Occurrence, Formation, Health Effects, and Control (pp. 36-50). (ACS Symposium Series; Vol. 995). American Chemical Society.