Comparative genomics of Erwinia amylovora and related Erwinia species-what do we learn?

Youfu Zhao, Mingsheng Qi

Research output: Contribution to journalReview articlepeer-review

Abstract

Erwinia amylovora, the causal agent of fire blight disease of apples and pears, is one of the most important plant bacterial pathogens with worldwide economic significance. Recent reports on the complete or draft genome sequences of four species in the genus Erwinia, including E. amylovora, E. pyrifoliae, E. tasmaniensis, and E. billingiae, have provided us near complete genetic information about this pathogen and its closely-related species. This review describes in silico subtractive hybridization-based comparative genomic analyses of eight genomes currently available, and highlights what we have learned from these comparative analyses, as well as genetic and functional genomic studies. Sequence analyses reinforce the assumption that E. amylovora is a relatively homogeneous species and support the current classification scheme of E. amylovora and its related species. The potential evolutionary origin of these Erwinia species is also proposed. The current understanding of the pathogen, its virulence mechanism and host specificity from genome sequencing data is summarized. Future research directions are also suggested,

Original languageEnglish (US)
Pages (from-to)627-639
Number of pages13
JournalGenes
Volume2
Issue number3
DOIs
StatePublished - Sep 2011

Keywords

  • Apple
  • Comparative genomics
  • Effector
  • Erwinia pyrifoliae
  • Exopolysaccharide amylovoran
  • Fire blight
  • In silico subtractive hybridization
  • Pear
  • Type III secretion
  • Virulence

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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