Comparative genomics of closely related salmonellae

Robert A. Edwards; Gary J. Olsen; Stanley R. Maloy

doi:10.1016/S0966-842X(01)02293-4

Comparative genomics of closely related salmonellae

Robert A. Edwards
, Gary J. Olsen
, Stanley R. Maloy

Research output: Contribution to journal › Review article › peer-review

Abstract

As the number of completed genome sequences increases, there is increasing emphasis on comparative genomic analysis of closely related organisms. Comparison of the similarities and differences between the five publicly available Salmonella genome sequences reveals extensive sequence conservation among the Salmonella serovars. However, horizontal gene transfer has provided each genome with between 10% and 12% of unique DNA. Genome comparisons of the closely related salmonellae emphasize the insights that can be gleaned from sequencing genomes of a single species.

Original language	English (US)
Pages (from-to)	94-99
Number of pages	6
Journal	Trends in Microbiology
Volume	10
Issue number	2
DOIs	https://doi.org/10.1016/S0966-842X(01)02293-4
State	Published - Feb 1 2002

ASJC Scopus subject areas

Microbiology
Microbiology (medical)
Infectious Diseases
Virology

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10.1016/S0966-842X(01)02293-4

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title = "Comparative genomics of closely related salmonellae",

abstract = "As the number of completed genome sequences increases, there is increasing emphasis on comparative genomic analysis of closely related organisms. Comparison of the similarities and differences between the five publicly available Salmonella genome sequences reveals extensive sequence conservation among the Salmonella serovars. However, horizontal gene transfer has provided each genome with between 10\% and 12\% of unique DNA. Genome comparisons of the closely related salmonellae emphasize the insights that can be gleaned from sequencing genomes of a single species.",

author = "Edwards, \{Robert A.\} and Olsen, \{Gary J.\} and Maloy, \{Stanley R.\}",

note = "We are indebted to both the Sanger Sequencing Center ( http://www.sanger.ac.uk/ ; Salmonella Typhi project led by Julian Parkhill) and the sequencing center at the Washington University, St. Louis ( http://genome.wustl.edu/ ; Salmonella Typhimurium and Paratyphi projects led by Rick Wilson and Michael McClelland) for sharing sequence data before publication. This work would not have been possible without their support. We thank David Graham, Nikos Kyrpides, Ross Overbeek and Jim Slauch for helpful discussions. This work was funded in part by grants from the University of Illinois Critical Research Initiative, the USDA (AG 00-35204-9196), and a grant from the University of Tennessee Center of Excellence in Genomics and Bioinformatics.",

year = "2002",

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doi = "10.1016/S0966-842X(01)02293-4",

language = "English (US)",

volume = "10",

pages = "94--99",

journal = "Trends in Microbiology",

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T1 - Comparative genomics of closely related salmonellae

AU - Edwards, Robert A.

AU - Olsen, Gary J.

AU - Maloy, Stanley R.

N1 - We are indebted to both the Sanger Sequencing Center ( http://www.sanger.ac.uk/ ; Salmonella Typhi project led by Julian Parkhill) and the sequencing center at the Washington University, St. Louis ( http://genome.wustl.edu/ ; Salmonella Typhimurium and Paratyphi projects led by Rick Wilson and Michael McClelland) for sharing sequence data before publication. This work would not have been possible without their support. We thank David Graham, Nikos Kyrpides, Ross Overbeek and Jim Slauch for helpful discussions. This work was funded in part by grants from the University of Illinois Critical Research Initiative, the USDA (AG 00-35204-9196), and a grant from the University of Tennessee Center of Excellence in Genomics and Bioinformatics.

PY - 2002/2/1

Y1 - 2002/2/1

N2 - As the number of completed genome sequences increases, there is increasing emphasis on comparative genomic analysis of closely related organisms. Comparison of the similarities and differences between the five publicly available Salmonella genome sequences reveals extensive sequence conservation among the Salmonella serovars. However, horizontal gene transfer has provided each genome with between 10% and 12% of unique DNA. Genome comparisons of the closely related salmonellae emphasize the insights that can be gleaned from sequencing genomes of a single species.

AB - As the number of completed genome sequences increases, there is increasing emphasis on comparative genomic analysis of closely related organisms. Comparison of the similarities and differences between the five publicly available Salmonella genome sequences reveals extensive sequence conservation among the Salmonella serovars. However, horizontal gene transfer has provided each genome with between 10% and 12% of unique DNA. Genome comparisons of the closely related salmonellae emphasize the insights that can be gleaned from sequencing genomes of a single species.

UR - https://www.scopus.com/pages/publications/0036468520

UR - https://www.scopus.com/pages/publications/0036468520#tab=citedBy

U2 - 10.1016/S0966-842X(01)02293-4

DO - 10.1016/S0966-842X(01)02293-4

M3 - Review article

C2 - 11827811

AN - SCOPUS:0036468520

SN - 0966-842X

VL - 10

SP - 94

EP - 99

JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 2

ER -

Comparative genomics of closely related salmonellae

Abstract

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