Comparative aspects of osteosarcoma pathogenesis in humans and dogs

Timothy M. Fan, Chand Khanna

Research output: Contribution to journalReview article

Abstract

Osteosarcoma (OS) is a primary and aggressive bone sarcoma affecting the skeleton of two principal species, human beings and canines. The biologic behavior of OS is conserved between people and dogs, and evidence suggests that fundamental discoveries in OS biology can be facilitated through detailed and comparative studies. In particular, the relative genetic homogeneity associated with specific dog breeds can provide opportunities to facilitate the discovery of key genetic drivers involved in OS pathogenesis, which, to-date, remain elusive. In this review, known causative factors that predispose to the development OS in human beings and dogs are summarized in detail. Based upon the commonalities shared in OS pathogenesis, it is likely that foundational discoveries in one species will be translationally relevant to the other and emphasizes the unique opportunities that might be gained through comparative scientific approaches.

Original languageEnglish (US)
Pages (from-to)210-230
Number of pages21
JournalVeterinary Sciences
Volume2
Issue number3
DOIs
StatePublished - Sep 1 2015

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osteosarcoma
Osteosarcoma
pathogenesis
Dogs
dogs
sarcoma
dog breeds
Skeleton
Sarcoma
skeleton
Canidae
bones
Bone and Bones
Biological Sciences

Keywords

  • Bone sarcoma
  • Comparative oncology
  • Conserved pathogenesis
  • Spontaneous tumor modeling

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Comparative aspects of osteosarcoma pathogenesis in humans and dogs. / Fan, Timothy M.; Khanna, Chand.

In: Veterinary Sciences, Vol. 2, No. 3, 01.09.2015, p. 210-230.

Research output: Contribution to journalReview article

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