TY - JOUR
T1 - Common evolutionary trends for SINE RNA structures
AU - Sun, Feng Jie
AU - Fleurdépine, Sophie
AU - Bousquet-Antonelli, Cécile
AU - Caetano-Anollés, Gustavo
AU - Deragon, Jean Marc
N1 - Funding Information:
This research was supported by CNRS, the European Commission (RIBOREG STREP program) (to J.M. Deragon) and NSF Project MCB-0343126 (to G. Caetano-Anollés). Any opinions, findings and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the funding agencies.
PY - 2007/1
Y1 - 2007/1
N2 - Short interspersed elements (SINEs) and long interspersed elements (LINEs) are transposable elements in eukaryotic genomes that mobilize through an RNA intermediate. Understanding their evolution is important because of their impact on the host genome. Most eukaryotic SINEs are ancestrally related to tRNA genes, although the typical tRNA cloverleaf structure is not apparent for most SINE consensus RNAs. Using a cladistic method where RNA structural components were coded as polarized and ordered multistate characters, we showed that related structural motifs are present in most SINE RNAs from mammals, fishes and plants, suggesting common selective constraints imposed at the SINE RNA structural level. Based on these results, we propose a general multistep model for the evolution of tRNA-related SINEs in eukaryotes.
AB - Short interspersed elements (SINEs) and long interspersed elements (LINEs) are transposable elements in eukaryotic genomes that mobilize through an RNA intermediate. Understanding their evolution is important because of their impact on the host genome. Most eukaryotic SINEs are ancestrally related to tRNA genes, although the typical tRNA cloverleaf structure is not apparent for most SINE consensus RNAs. Using a cladistic method where RNA structural components were coded as polarized and ordered multistate characters, we showed that related structural motifs are present in most SINE RNAs from mammals, fishes and plants, suggesting common selective constraints imposed at the SINE RNA structural level. Based on these results, we propose a general multistep model for the evolution of tRNA-related SINEs in eukaryotes.
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U2 - 10.1016/j.tig.2006.11.005
DO - 10.1016/j.tig.2006.11.005
M3 - Article
C2 - 17126948
AN - SCOPUS:33845637289
VL - 23
SP - 26
EP - 33
JO - Trends in Genetics
JF - Trends in Genetics
SN - 0168-9525
IS - 1
ER -