Common bean protein hydrolysate modulates lipid metabolism and prevents endothelial dysfunction in BALB/c mice fed an atherogenic diet

Mariana J.C. Gomes, Sâmara L.S. Lima, Natália E.G. Alves, Andressa Assis, Maria E.C. Moreira, Renata C.L. Toledo, Carla O.B. Rosa, Olívia R. Teixeira, Priscila Z. Bassinello, Elvira G. De Mejía, Hércia S.D. Martino

Research output: Contribution to journalArticle

Abstract

Background and aims: Common beans (Phaseolus vulgaris L.) protein hydrolysate is a source of bioactive peptides with known health benefits. The aim of this study was to evaluate the effect of common bean protein hydrolysate on lipid metabolism and endothelial function in male adult BALB/c mice fed an atherogenic diet for nine weeks. Methods and results: Male adult mice were divided into three experimental groups (n = 12) and fed with normal control diet; atherogenic diet and atherogenic diet added with bean protein hydrolysate (700 mg/kg/day) for nine weeks. Food intake, weight gain, lipid profile, Atherogenic Index of Plasma, inflammation biomarkers and endothelial function were evaluated. APH group presented reduced feed intake, weight gain, lipid profile, tumor necrosis factor-α, angiotensin II (94% and 79%, respectively) and increased endothelial nitric oxide synthase (62%). Conclusions: Protein hydrolysate showed hypocholesterolemic activity preventing inflammation and dysfunction of vascular endothelium, in addition to decreasing oxidative stress, indicating an adjuvant effect on reducing atherogenic risk.

Original languageEnglish (US)
Pages (from-to)141-150
Number of pages10
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume30
Issue number1
DOIs
StatePublished - Jan 3 2020

Keywords

  • Angiotensin II
  • Antioxidant capacity
  • Bioactive peptides
  • Common bean
  • Endothelial dysfunction
  • e-NOS

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Gomes, M. J. C., Lima, S. L. S., Alves, N. E. G., Assis, A., Moreira, M. E. C., Toledo, R. C. L., Rosa, C. O. B., Teixeira, O. R., Bassinello, P. Z., De Mejía, E. G., & Martino, H. S. D. (2020). Common bean protein hydrolysate modulates lipid metabolism and prevents endothelial dysfunction in BALB/c mice fed an atherogenic diet. Nutrition, Metabolism and Cardiovascular Diseases, 30(1), 141-150. https://doi.org/10.1016/j.numecd.2019.07.020