Combining gene therapy and nanomedicine to enhance the therapeutic potential of T cells

Yoonsu Choi, Hiroki Torikai, Daniel Y. Lee, Zheng Li, Diana Lo, Guoting Qin, Chine H. Tung, Ennio Tasciotti, Robert Raphael, Sibani L. Biswal, Sonny Ang, Dean A. Lee, King C Li, Laurence J.N. Cooper

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

To undertake adoptive immunotherapy for lung cancer, we have combined nanotechnology, bioengineering, and gene therapy to use T cells as a vehicle for the targeted delivery of nanoparticles (NPs) to the lung tumor microenvironment. In this project, we have developed a high throughput electroporator to manipulate large numbers of T cells ex vivo for clinical uses. A proprietary electroporator is designed to electro-transfer RNA species to redirect T-cell specificity and NPs that can be functionalized to enhance T-cell biology. By introducing both transgenes and NPs, we are generating T cells that can be rapidly modified to act as a drug-delivery system for targeted therapy of lung cancer.

Original languageEnglish (US)
Title of host publicationNanotechnology 2010
Subtitle of host publicationBio Sensors, Instruments, Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010
Pages376-379
Number of pages4
StatePublished - Nov 9 2010
Externally publishedYes
EventNanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010 - Anaheim, CA, United States
Duration: Jun 21 2010Jun 24 2010

Publication series

NameNanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010
Volume3

Other

OtherNanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010
CountryUnited States
CityAnaheim, CA
Period6/21/106/24/10

Keywords

  • Electroporation
  • High throughput
  • MRNA
  • T cell
  • Targeted drug delivery

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering
  • Electrical and Electronic Engineering

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  • Cite this

    Choi, Y., Torikai, H., Lee, D. Y., Li, Z., Lo, D., Qin, G., Tung, C. H., Tasciotti, E., Raphael, R., Biswal, S. L., Ang, S., Lee, D. A., Li, K. C., & Cooper, L. J. N. (2010). Combining gene therapy and nanomedicine to enhance the therapeutic potential of T cells. In Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010 (pp. 376-379). (Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010; Vol. 3).