@inproceedings{d090040ea4ad4f33b667157a73aa6e7e,
title = "Combining gene therapy and nanomedicine to enhance the therapeutic potential of T cells",
abstract = "To undertake adoptive immunotherapy for lung cancer, we have combined nanotechnology, bioengineering, and gene therapy to use T cells as a vehicle for the targeted delivery of nanoparticles (NPs) to the lung tumor microenvironment. In this project, we have developed a high throughput electroporator to manipulate large numbers of T cells ex vivo for clinical uses. A proprietary electroporator is designed to electro-transfer RNA species to redirect T-cell specificity and NPs that can be functionalized to enhance T-cell biology. By introducing both transgenes and NPs, we are generating T cells that can be rapidly modified to act as a drug-delivery system for targeted therapy of lung cancer.",
keywords = "Electroporation, High throughput, MRNA, T cell, Targeted drug delivery",
author = "Yoonsu Choi and Hiroki Torikai and Lee, {Daniel Y.} and Zheng Li and Diana Lo and Guoting Qin and Tung, {Chine H.} and Ennio Tasciotti and Robert Raphael and Biswal, {Sibani L.} and Sonny Ang and Lee, {Dean A.} and Li, {King C} and Cooper, {Laurence J.N.}",
year = "2010",
month = nov,
day = "9",
language = "English (US)",
isbn = "9781439834152",
series = "Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010",
pages = "376--379",
booktitle = "Nanotechnology 2010",
note = "Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010 ; Conference date: 21-06-2010 Through 24-06-2010",
}