Combining C6 and C5 sugar metabolism for enhancing microbial bioconversion

Guo Chang Zhang, Jing Jing Liu, In Iok Kong, Suryang Kwak, Yong Su Jin

Research output: Contribution to journalReview articlepeer-review


Mixed sugars, which are often obtained from renewable biomass, can be converted into biofuels and chemicals by microbial conversion. This sustainable production process can also mitigate man-made climate change when used to petroleum-based fuel and chemical production. In contrast to single sugar fermentations, such as corn-based or sugarcane-based ethanol fermentations, mixed sugar fermentations present significant challenges for cost-effective production of the target products. In particular, inefficient and slow microbial fermentation of non-glucose sugars, such as galactose and xylose from the depolymerization of marine and terrestrial biomass has been a major obstacle. Nonetheless, simultaneous utilization of mixed sugars has recently been demonstrated through innovative metabolic engineering strategies and the discovery of transporters, and metabolic pathways which are necessary for co-fermenting glucose and non-glucose sugars.

Original languageEnglish (US)
Pages (from-to)49-57
Number of pages9
JournalCurrent Opinion in Chemical Biology
StatePublished - Dec 1 2015

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry


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