TY - JOUR
T1 - Combined experimental and computational strategies define an expansive regulon for GcvB small RNA
AU - Vanderpool, Carin K.
PY - 2011/9
Y1 - 2011/9
N2 - The bacterial small RNA GcvB has been known as a translational repressor of mRNAs encoding amino acid transporters and has been postulated to limit uptake of unnecessary amino acids under nutrient-rich conditions. In this issue of Molecular Microbiology, Sharma (2011) provide evidence for a much broader role for GcvB as a global regulator of amino acid metabolism. Using a unique combination of experimental and biocomputational approaches, the authors triple the size of the GcvB regulon, making it the largest sRNA regulon defined to date.
AB - The bacterial small RNA GcvB has been known as a translational repressor of mRNAs encoding amino acid transporters and has been postulated to limit uptake of unnecessary amino acids under nutrient-rich conditions. In this issue of Molecular Microbiology, Sharma (2011) provide evidence for a much broader role for GcvB as a global regulator of amino acid metabolism. Using a unique combination of experimental and biocomputational approaches, the authors triple the size of the GcvB regulon, making it the largest sRNA regulon defined to date.
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U2 - 10.1111/j.1365-2958.2011.07780.x
DO - 10.1111/j.1365-2958.2011.07780.x
M3 - Comment/debate
C2 - 21815948
AN - SCOPUS:80051936841
SN - 0950-382X
VL - 81
SP - 1129
EP - 1132
JO - Molecular Microbiology
JF - Molecular Microbiology
IS - 5
ER -