Combined and iterative use of computational design and directed evolution for protein-ligand binding design

Keyphrases

• Directed Evolution 100%
• Evolutionary Design 100%
• Protein-ligand Binding 100%
• Computational Design 100%
• Ligand Binding Design 100%
• Systematic Strategies 33%
• Systems-based 33%
• Membrane Estrogen Receptor 33%
• Yeast Two-hybrid 33%
• Structure-guided 33%
• Protein-ligand Interaction 33%
• Novel Genes 33%
• Complementary and 33%
• Novel Interactions 33%
• Gene Switch 33%
• Phenotypic Screening 33%
• Synthetic Ligands 33%
• Site-saturation mutagenesis 33%
• Interaction Design 33%
• Synthetic Humans 33%
• Orthogonal Interaction 33%

Biochemistry, Genetics and Molecular Biology

• Ligand Binding 100%
• Protein Ligand 100%
• Mutagenesis 50%
• Estrogen Receptor 50%
• Two-Hybrid Screening 50%
• Locus Control Region 50%