Combinatorial therapy for triple negative breast cancer using hyperstar polymer-based nanoparticles

S. K. Misra, X. Wang, I. Srivastava, M. K. Imgruet, R. W. Graff, A. Ohoka, T. L. Kampert, H. Gao, D. Pan

Research output: Contribution to journalArticlepeer-review

Abstract

We report the ability of a novel combinatorial therapy obtained from nanoparticles of hyperstar polymers encompassing drugs to selectively target triple negative breast cancer (TNBC) cell proliferation through STAT3 and topoisomerase-II pathways. This nano-cocktail was at least two to four fold better than the individual drugs and 6-20 times more selective than the parent drugs.

Original languageEnglish (US)
Pages (from-to)16710-16713
Number of pages4
JournalChemical Communications
Volume51
Issue number93
DOIs
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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