TY - JOUR
T1 - Comb-push ultrasound shear elastography of breast masses
T2 - Initial results show promise
AU - Denis, Max
AU - Mehrmohammadi, Mohammad
AU - Song, Pengfei
AU - Meixner, Duane D.
AU - Fazzio, Robert T.
AU - Pruthi, Sandhya
AU - Whaley, Dana H.
AU - Chen, Shigao
AU - Fatemi, Mostafa
AU - Alizad, Azra
N1 - Funding Information:
PS and SC are inventors of patents generally related to the subject of this manuscript, which are assigned to and owned by the Mayo Clinic. Listed are the following patents relevant to this manuscript: 1. System and method for shear wave elastography by transmitting ultrasound with subgroups of ultrasound transducer elements (WO 2014055973 A1). 2. Ultrasound vibrometry with unfocused ultrasound (WO 2012116364 A1). The General Electric Company has licensed and is developing products based on this technology. The General Electric Company had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. This work was solely supported by the National Institutes of Health, grant R01CA148994. This research was conducted in compliance with oversight by the Mayo Clinic Conflict of Interest Review Board. The declared interests do not alter the adherence of the authors to the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.
Publisher Copyright:
© 2015 Denis et al.
PY - 2015/3/16
Y1 - 2015/3/16
N2 - Purpose or Objective: To evaluate the performance of Comb-push Ultrasound Shear Elastography (CUSE) for classification of breast masses. Materials and Methods: CUSE is an ultrasound-based quantitative two-dimensional shear wave elasticity imaging technique, which utilizes multiple laterally distributed acoustic radiation force (ARF) beams to simultaneously excite the tissue and induce shear waves. Female patients who were categorized as having suspicious breast masses underwent CUSE evaluations prior to biopsy. An elasticity estimate within the breast mass was obtained from the CUSE shear wave speed map. Elasticity estimates of various types of benign and malignant masses were compared with biopsy results. Results: Fifty-four female patients with suspicious breast masses from our ongoing study are presented. Our cohort included 31 malignant and 23 benign breast masses. Our results indicate that the mean shear wave speed was significantly higher in malignant masses (6 ± 1.58 m/s) in comparison to benign masses (3.65 ± 1.36 m/s). Therefore, the stiffness of the mass quantified by the Young's modulus is significantly higher in malignant masses. According to the receiver operating characteristic curve (ROC), the optimal cut-off value of 83 kPa yields 87.10% sensitivity, 82.61% specificity, and 0.88 for the area under the curve (AUC). Conclusion: CUSE has the potential for clinical utility as a quantitative diagnostic imaging tool adjunct to B-mode ultrasound for differentiation of malignant and benign breast masses.
AB - Purpose or Objective: To evaluate the performance of Comb-push Ultrasound Shear Elastography (CUSE) for classification of breast masses. Materials and Methods: CUSE is an ultrasound-based quantitative two-dimensional shear wave elasticity imaging technique, which utilizes multiple laterally distributed acoustic radiation force (ARF) beams to simultaneously excite the tissue and induce shear waves. Female patients who were categorized as having suspicious breast masses underwent CUSE evaluations prior to biopsy. An elasticity estimate within the breast mass was obtained from the CUSE shear wave speed map. Elasticity estimates of various types of benign and malignant masses were compared with biopsy results. Results: Fifty-four female patients with suspicious breast masses from our ongoing study are presented. Our cohort included 31 malignant and 23 benign breast masses. Our results indicate that the mean shear wave speed was significantly higher in malignant masses (6 ± 1.58 m/s) in comparison to benign masses (3.65 ± 1.36 m/s). Therefore, the stiffness of the mass quantified by the Young's modulus is significantly higher in malignant masses. According to the receiver operating characteristic curve (ROC), the optimal cut-off value of 83 kPa yields 87.10% sensitivity, 82.61% specificity, and 0.88 for the area under the curve (AUC). Conclusion: CUSE has the potential for clinical utility as a quantitative diagnostic imaging tool adjunct to B-mode ultrasound for differentiation of malignant and benign breast masses.
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U2 - 10.1371/journal.pone.0119398
DO - 10.1371/journal.pone.0119398
M3 - Article
C2 - 25774978
AN - SCOPUS:84924943591
SN - 1932-6203
VL - 10
JO - PloS one
JF - PloS one
IS - 3
M1 - e0119398
ER -