Colorimetric plasmon resonance microfluidics on nanohole array sensors

Austin Hsiao; Manas Ranjan Gartia; Te Wei Chang; Xinhao Wang; Pakapreud Khumwan; Gang Logan Liu

doi:10.1016/j.sbsr.2015.06.001

Colorimetric plasmon resonance microfluidics on nanohole array sensors

Austin Hsiao, Manas Ranjan Gartia, Te Wei Chang, Xinhao Wang, Pakapreud Khumwan, Gang Logan Liu

Research output: Contribution to journal › Article › peer-review

Abstract

We present the label-free colorimetric visualization in microfluidics using plasmon resonance on a large-area and over a wide field-of-view (>100mm²) nanohole array device called nanoLycurgus Cup Array (nanoLCA). We demonstrate the spectral detection and colorimetric sensing of static solutions of different concentrations of glycerol-water confined in parallel microfluidic channels integrated with nanoLCA. Taking advantage of the large sensor area and the colorimetric sensing capability of nanoLCA, we visualize in real-time the modulation of two immiscible solutions (water and oil), generated with integrated flow-focus microfluidics, in a label-free manner. Finite Element Method (FEM) based simulation tool (COMSOL) was used to verify the droplet formation in the microfluidics. Finite Difference Time Domain (FDTD) electromagnetic simulation was used to identify the resonance modes of the plasmonic sensor. Finally, we demonstrate the real-time monitoring of streptavidin-biotin biomolecular interaction with the plasmonic biosensor.

Original language	English (US)
Pages (from-to)	24-32
Number of pages	9
Journal	Sensing and Bio-Sensing Research
Volume	5
DOIs	https://doi.org/10.1016/j.sbsr.2015.06.001
State	Published - 2015

Keywords

Colorimetric sensor
Droplet formation
Microfluidics
Nanohole array
Protein binding
Surface plasmon

ASJC Scopus subject areas

Biotechnology
Electronic, Optical and Magnetic Materials
Signal Processing
Electrical and Electronic Engineering

Online availability

10.1016/j.sbsr.2015.06.001

Library availability

Discover UIUC Full Text

Cite this

@article{5a5469aa28bf4e37909e5028def5c6c0,

title = "Colorimetric plasmon resonance microfluidics on nanohole array sensors",

abstract = "We present the label-free colorimetric visualization in microfluidics using plasmon resonance on a large-area and over a wide field-of-view (>100mm2) nanohole array device called nanoLycurgus Cup Array (nanoLCA). We demonstrate the spectral detection and colorimetric sensing of static solutions of different concentrations of glycerol-water confined in parallel microfluidic channels integrated with nanoLCA. Taking advantage of the large sensor area and the colorimetric sensing capability of nanoLCA, we visualize in real-time the modulation of two immiscible solutions (water and oil), generated with integrated flow-focus microfluidics, in a label-free manner. Finite Element Method (FEM) based simulation tool (COMSOL) was used to verify the droplet formation in the microfluidics. Finite Difference Time Domain (FDTD) electromagnetic simulation was used to identify the resonance modes of the plasmonic sensor. Finally, we demonstrate the real-time monitoring of streptavidin-biotin biomolecular interaction with the plasmonic biosensor.",

keywords = "Colorimetric sensor, Droplet formation, Microfluidics, Nanohole array, Protein binding, Surface plasmon",

author = "Austin Hsiao and Gartia, {Manas Ranjan} and Chang, {Te Wei} and Xinhao Wang and Pakapreud Khumwan and Liu, {Gang Logan}",

year = "2015",

doi = "10.1016/j.sbsr.2015.06.001",

language = "English (US)",

volume = "5",

pages = "24--32",

journal = "Sensing and Bio-Sensing Research",

issn = "2214-1804",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Colorimetric plasmon resonance microfluidics on nanohole array sensors

AU - Hsiao, Austin

AU - Gartia, Manas Ranjan

AU - Chang, Te Wei

AU - Wang, Xinhao

AU - Khumwan, Pakapreud

AU - Liu, Gang Logan

PY - 2015

Y1 - 2015

N2 - We present the label-free colorimetric visualization in microfluidics using plasmon resonance on a large-area and over a wide field-of-view (>100mm2) nanohole array device called nanoLycurgus Cup Array (nanoLCA). We demonstrate the spectral detection and colorimetric sensing of static solutions of different concentrations of glycerol-water confined in parallel microfluidic channels integrated with nanoLCA. Taking advantage of the large sensor area and the colorimetric sensing capability of nanoLCA, we visualize in real-time the modulation of two immiscible solutions (water and oil), generated with integrated flow-focus microfluidics, in a label-free manner. Finite Element Method (FEM) based simulation tool (COMSOL) was used to verify the droplet formation in the microfluidics. Finite Difference Time Domain (FDTD) electromagnetic simulation was used to identify the resonance modes of the plasmonic sensor. Finally, we demonstrate the real-time monitoring of streptavidin-biotin biomolecular interaction with the plasmonic biosensor.

AB - We present the label-free colorimetric visualization in microfluidics using plasmon resonance on a large-area and over a wide field-of-view (>100mm2) nanohole array device called nanoLycurgus Cup Array (nanoLCA). We demonstrate the spectral detection and colorimetric sensing of static solutions of different concentrations of glycerol-water confined in parallel microfluidic channels integrated with nanoLCA. Taking advantage of the large sensor area and the colorimetric sensing capability of nanoLCA, we visualize in real-time the modulation of two immiscible solutions (water and oil), generated with integrated flow-focus microfluidics, in a label-free manner. Finite Element Method (FEM) based simulation tool (COMSOL) was used to verify the droplet formation in the microfluidics. Finite Difference Time Domain (FDTD) electromagnetic simulation was used to identify the resonance modes of the plasmonic sensor. Finally, we demonstrate the real-time monitoring of streptavidin-biotin biomolecular interaction with the plasmonic biosensor.

KW - Colorimetric sensor

KW - Droplet formation

KW - Microfluidics

KW - Nanohole array

KW - Protein binding

KW - Surface plasmon

UR - http://www.scopus.com/inward/record.url?scp=84934961775&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84934961775&partnerID=8YFLogxK

U2 - 10.1016/j.sbsr.2015.06.001

DO - 10.1016/j.sbsr.2015.06.001

M3 - Article

AN - SCOPUS:84934961775

SN - 2214-1804

VL - 5

SP - 24

EP - 32

JO - Sensing and Bio-Sensing Research

JF - Sensing and Bio-Sensing Research

ER -

Colorimetric plasmon resonance microfluidics on nanohole array sensors

Abstract

Keywords

ASJC Scopus subject areas

Online availability

Library availability

Related links

Fingerprint

Cite this