Collapse and repair of replication forks in Escherichia coli

Research output: Contribution to journalReview articlepeer-review


Single‐strand interruptions in a template DNA are likely to cause collapse of replication forks. We propose a model for the repair of collapsed replication forks in Escherichia coli by the RecBCD recombinational pathway. The model gives reasons for the preferential orientation of Chi sites in the E. coli chromosome and accounts for the hyper‐rec phenotype of the strains with increased numbers of single‐strand interruptions in their DNA. On the basis of the model we offer schemes for various repeat‐mediated recombinational events and discuss a mechanism for quasi‐conservative DNA replication explaining the recombinational repair‐associated mutagenesis.

Original languageEnglish (US)
Pages (from-to)373-384
Number of pages12
JournalMolecular Microbiology
Issue number3
StatePublished - May 1995
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology


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