Collagen scaffolds incorporating coincident gradations of instructive structural and biochemical cues for osteotendinous junction engineering

Steven R. Caliari, Daniel W. Weisgerber, William K. Grier, Ziad Mahmassani, Marni D. Boppart, Brendan A C Harley

Research output: Contribution to journalArticlepeer-review

Abstract

A fully 3D biomaterial containing overlapping gradations of structural, compositional, and biomolecular cues as seen in native orthopedic interfaces is described for the first time. A multi-compartment collagen scaffold is created for engineering tendon-bone junctions connected by a continuous interface that can induce spatially specific MSC differentiation down tenogenic and osteogenic lineages without the use of differentiation media.

Original languageEnglish (US)
Pages (from-to)831-837
Number of pages7
JournalAdvanced Healthcare Materials
Volume4
Issue number6
DOIs
StatePublished - Apr 1 2015

Keywords

  • Bone
  • Collagen
  • Mesenchymal stem cells
  • Orthopedic interfaces
  • Tendon

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

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