Collagen scaffolds incorporating coincident gradations of instructive structural and biochemical cues for osteotendinous junction engineering

Steven R. Caliari; Daniel W. Weisgerber; William K. Grier; Ziad Mahmassani; Marni D. Boppart; Brendan A C Harley

doi:10.1002/adhm.201400809

Collagen scaffolds incorporating coincident gradations of instructive structural and biochemical cues for osteotendinous junction engineering

Steven R. Caliari, Daniel W. Weisgerber, William K. Grier, Ziad Mahmassani, Marni D. Boppart, Brendan A C Harley

Research output: Contribution to journal › Article › peer-review

Abstract

A fully 3D biomaterial containing overlapping gradations of structural, compositional, and biomolecular cues as seen in native orthopedic interfaces is described for the first time. A multi-compartment collagen scaffold is created for engineering tendon-bone junctions connected by a continuous interface that can induce spatially specific MSC differentiation down tenogenic and osteogenic lineages without the use of differentiation media.

Original language	English (US)
Pages (from-to)	831-837
Number of pages	7
Journal	Advanced Healthcare Materials
Volume	4
Issue number	6
DOIs	https://doi.org/10.1002/adhm.201400809
State	Published - Apr 1 2015

Keywords

Bone
Collagen
Mesenchymal stem cells
Orthopedic interfaces
Tendon

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering
Pharmaceutical Science

Online availability

10.1002/adhm.201400809

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title = "Collagen scaffolds incorporating coincident gradations of instructive structural and biochemical cues for osteotendinous junction engineering",

abstract = "A fully 3D biomaterial containing overlapping gradations of structural, compositional, and biomolecular cues as seen in native orthopedic interfaces is described for the first time. A multi-compartment collagen scaffold is created for engineering tendon-bone junctions connected by a continuous interface that can induce spatially specific MSC differentiation down tenogenic and osteogenic lineages without the use of differentiation media.",

keywords = "Bone, Collagen, Mesenchymal stem cells, Orthopedic interfaces, Tendon",

author = "Caliari, {Steven R.} and Weisgerber, {Daniel W.} and Grier, {William K.} and Ziad Mahmassani and Boppart, {Marni D.} and Harley, {Brendan A C}",

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AU - Grier, William K.

AU - Mahmassani, Ziad

AU - Boppart, Marni D.

AU - Harley, Brendan A C

PY - 2015/4/1

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AB - A fully 3D biomaterial containing overlapping gradations of structural, compositional, and biomolecular cues as seen in native orthopedic interfaces is described for the first time. A multi-compartment collagen scaffold is created for engineering tendon-bone junctions connected by a continuous interface that can induce spatially specific MSC differentiation down tenogenic and osteogenic lineages without the use of differentiation media.

KW - Bone

KW - Collagen

KW - Mesenchymal stem cells

KW - Orthopedic interfaces

KW - Tendon

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Collagen scaffolds incorporating coincident gradations of instructive structural and biochemical cues for osteotendinous junction engineering

Abstract

Keywords

ASJC Scopus subject areas

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