Abstract
A fully 3D biomaterial containing overlapping gradations of structural, compositional, and biomolecular cues as seen in native orthopedic interfaces is described for the first time. A multi-compartment collagen scaffold is created for engineering tendon-bone junctions connected by a continuous interface that can induce spatially specific MSC differentiation down tenogenic and osteogenic lineages without the use of differentiation media.
Original language | English (US) |
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Pages (from-to) | 831-837 |
Number of pages | 7 |
Journal | Advanced Healthcare Materials |
Volume | 4 |
Issue number | 6 |
DOIs | |
State | Published - Apr 1 2015 |
Keywords
- Bone
- Collagen
- Mesenchymal stem cells
- Orthopedic interfaces
- Tendon
ASJC Scopus subject areas
- Biomaterials
- Biomedical Engineering
- Pharmaceutical Science