Collagen scaffold arrays for combinatorial screening of biophysical and biochemical regulators of cell behavior

Steven R. Caliari, Emily A. Gonnerman, William K. Grier, Daniel W. Weisgerber, Jessica M. Banks, Aurora J. Alsop, Jae Sung Lee, Ryan C. Bailey, Brendan A.C. Harley

Research output: Contribution to journalArticlepeer-review

Abstract

Arrays of 3D macroporous collagen scaffolds with orthogonal gradations of structural and biomolecular cues are described. Gradient maker technology is applied to create linear biomolecular gradients within microstructurally distinct sections of a single CG scaffold array. The array set up is used to explore cell behaviors including proliferation and regulation of stem cell fate.

Original languageEnglish (US)
Pages (from-to)58-64
Number of pages7
JournalAdvanced Healthcare Materials
Volume4
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • Arrays
  • Collagen
  • Freeze-drying
  • Gradients
  • Mesenchymal stem cells

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

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