Coinfection with multiple strains of bovine papular stomatitis virus

Tao Huang, Edan R. Tulman, Diego G. Diel, Sushil Khatiwada, Will Sims, John F. Edwards, Xintian Wen, Gerald F. Kutish, Daniel L. Rock, Gustavo Delhon

Research output: Contribution to journalArticlepeer-review


Bovine papular stomatitis virus (BPSV) infects cattle and, occupationally, humans. Prevalent subclinical infections, frequent reinfections, and virus persistence in healthy animals compound a poorly understood, but likely complex, scenario of BPSV perpetuation and transmission in nature. Here, we report the isolation of multiple BPSV strains coinfecting a single animal. Whole-genome analysis of isolated BPSV strains revealed genomic variability likely affecting virus virulence and infectivity. Further, incongruent phylogenetic relationships between viruses suggested genomic recombination. These results have significant implications for parapoxvirus infection biology and virus evolution in nature.

Original languageEnglish (US)
Pages (from-to)1527-1532
Number of pages6
JournalArchives of Virology
Issue number6
StatePublished - Jun 1 2015

ASJC Scopus subject areas

  • Virology


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