Coherent optical imaging and guided interventions in breast cancer: Translating technology into clinical applications

Stephen A. Boppart, Freddy T. Nguyen, Adam M. Zysk, Eric J. Chaney, Jan G. Kotynek, Uretz J. Oliphant, Frank J. Bellafiore, Kendrith M. Rowland, Patricia A. Johnson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Breast cancer continues to be one of the most widely diagnosed forms of cancer in women and the second leading type of cancer deaths for women. The metastatic spread and staging of breast cancer is typically evaluated through the nodal assessment of the regional lymphatic system, and often this is performed during the surgical resection of the tumor mass. The recurrence rate of breast cancer is highly dependent on several factors including the complete removal of the primary tumor during surgery, and the presence of cancer cells in involved lymph nodes. Hence, developing means to more accurately resect tumor cells, along with the tumor mass, and ensure negative surgical margins, offers the potential to impact outcomes of breast cancer. The use of diffuse optical tomography has been applied for screening optical mammography applications as an alternative to standard x-ray mammography. The use of coherence ranging and coherent optical imaging in breast tissue has also found numerous applications, including intra-operative assessment of tumor margin status during lumpectomy procedures, assessment of lymph node changes for staging metastatic spread, and for guiding needle-biopsy procedures. The development, pre-clinical testing, and translation of techniques such as low-coherence interferometry (LCI) and optical coherence tomography (OCT) into clinical applications in breast cancer is demonstrated in these feasibility studies.

Original languageEnglish (US)
Title of host publicationBiophotonics
Subtitle of host publicationPhotonic Solutions for Better Health Care
DOIs
StatePublished - Jun 18 2008
EventBiophotonics: Photonic Solutions for Better Health Care - Strasbourg, France
Duration: Apr 8 2008Apr 10 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6991
ISSN (Print)1605-7422

Other

OtherBiophotonics: Photonic Solutions for Better Health Care
CountryFrance
CityStrasbourg
Period4/8/084/10/08

Keywords

  • Biomedical optics
  • Breast cancer
  • Clinical imaging
  • Image guided surgery
  • Lymph node
  • Metastasis
  • Optical coherence tomography

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Boppart, S. A., Nguyen, F. T., Zysk, A. M., Chaney, E. J., Kotynek, J. G., Oliphant, U. J., Bellafiore, F. J., Rowland, K. M., & Johnson, P. A. (2008). Coherent optical imaging and guided interventions in breast cancer: Translating technology into clinical applications. In Biophotonics: Photonic Solutions for Better Health Care [699102] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6991). https://doi.org/10.1117/12.780168