Nonlinear biomedical imaging has not benefited from the well-known techniques of fiber supercontinuum generation for reasons such as poor coherence (or high noise), insufficient controllability, low spectral power intensity, and inadequate portability. Fortunately, a few techniques involving nonlinear fiber optics and femtosecond fiber laser development have emerged to overcome these critical limitations. These techniques pave the way for conducting point-of-care nonlinear biomedical imaging by a low-maintenance cost-effective coherent fiber supercontinuum laser, which covers a broad emission wavelength of 350-1700 nm. A prototype of this laser has been demonstrated in label-free multimodal nonlinear imaging of cell and tissue samples.

Original languageEnglish (US)
Title of host publicationOptics in Health Care and Biomedical Optics V
StatePublished - 2012
EventOptics in Health Care and Biomedical Optics V - Beijing, China
Duration: Nov 5 2012Nov 7 2012

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherOptics in Health Care and Biomedical Optics V


  • femtosecond laser
  • Multiphoton microscopy
  • nonlinear fiber optics
  • photonic crystal fiber
  • supercontinuum

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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