Cognitive deficits in depression and functional specificity of regional brain activity

Rebecca L. Levin; Wendy Heller; Aprajita Mohanty; John D. Herrington; Gregory A. Miller

doi:10.1007/s10608-007-9128-z

Cognitive deficits in depression and functional specificity of regional brain activity

Rebecca L. Levin, Wendy Heller, Aprajita Mohanty, John D. Herrington, Gregory A. Miller

Research output: Contribution to journal › Review article › peer-review

Abstract

The growing literature on cognitive deficits in depression is considered in light of regional brain activity as well as comorbid anxiety and life stressors. Cognitive impairments associated with depression are reviewed, with an emphasis on various aspects of executive function such as memory, attention, and problem-solving. These deficits are related to patterns of brain activity observed in prefrontal, anterior cingulate, and parietal cortices, as well as in subcortical regions. Evidence for the largely unexplored role of environmental stressors in depression and their impact on cognition and brain function is also examined, and promising avenues of additional research are noted. In addition to promoting interdisciplinary research, systematically assessing variables such as cognitive performance, comorbid anxiety, and relevant stressors may elucidate distinct patterns of brain function and cognition that could inform prevention and intervention.

Original language	English (US)
Pages (from-to)	211-233
Number of pages	23
Journal	Cognitive Therapy and Research
Volume	31
Issue number	2
DOIs	https://doi.org/10.1007/s10608-007-9128-z
State	Published - Apr 2007

Keywords

Anterior cingulate cortex
Anxiety
Depression
Executive function
Prefrontal cortex
Stress

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Clinical Psychology

Online availability

10.1007/s10608-007-9128-z

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title = "Cognitive deficits in depression and functional specificity of regional brain activity",

abstract = "The growing literature on cognitive deficits in depression is considered in light of regional brain activity as well as comorbid anxiety and life stressors. Cognitive impairments associated with depression are reviewed, with an emphasis on various aspects of executive function such as memory, attention, and problem-solving. These deficits are related to patterns of brain activity observed in prefrontal, anterior cingulate, and parietal cortices, as well as in subcortical regions. Evidence for the largely unexplored role of environmental stressors in depression and their impact on cognition and brain function is also examined, and promising avenues of additional research are noted. In addition to promoting interdisciplinary research, systematically assessing variables such as cognitive performance, comorbid anxiety, and relevant stressors may elucidate distinct patterns of brain function and cognition that could inform prevention and intervention.",

keywords = "Anterior cingulate cortex, Anxiety, Depression, Executive function, Prefrontal cortex, Stress",

author = "Levin, {Rebecca L.} and Wendy Heller and Aprajita Mohanty and Herrington, {John D.} and Miller, {Gregory A.}",

note = "Funding Information: Acknowledgments The authors thank Amanda Howald for assistance preparing this manuscript and Anna S. Engels and Sarah M. Sass for their input on this manuscript. The present work was supported by NIDA (R21 DA14111), NIMH (R01 MH61358, T32 MH19554), and the University of Illinois Funding Information: Intercampus Research Initiative in Biotechnology. John D. Herrington was a predoctoral trainee in the Quantitative Methods program of the Department of Psychology, University of Illinois at Urbana-Champaign, supported by NIMH T32 MH14257. He is currently affiliated with the Child Study Center, Yale University, New Haven, CT.",

year = "2007",

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doi = "10.1007/s10608-007-9128-z",

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AU - Heller, Wendy

AU - Mohanty, Aprajita

AU - Herrington, John D.

AU - Miller, Gregory A.

N1 - Funding Information: Acknowledgments The authors thank Amanda Howald for assistance preparing this manuscript and Anna S. Engels and Sarah M. Sass for their input on this manuscript. The present work was supported by NIDA (R21 DA14111), NIMH (R01 MH61358, T32 MH19554), and the University of Illinois Funding Information: Intercampus Research Initiative in Biotechnology. John D. Herrington was a predoctoral trainee in the Quantitative Methods program of the Department of Psychology, University of Illinois at Urbana-Champaign, supported by NIMH T32 MH14257. He is currently affiliated with the Child Study Center, Yale University, New Haven, CT.

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N2 - The growing literature on cognitive deficits in depression is considered in light of regional brain activity as well as comorbid anxiety and life stressors. Cognitive impairments associated with depression are reviewed, with an emphasis on various aspects of executive function such as memory, attention, and problem-solving. These deficits are related to patterns of brain activity observed in prefrontal, anterior cingulate, and parietal cortices, as well as in subcortical regions. Evidence for the largely unexplored role of environmental stressors in depression and their impact on cognition and brain function is also examined, and promising avenues of additional research are noted. In addition to promoting interdisciplinary research, systematically assessing variables such as cognitive performance, comorbid anxiety, and relevant stressors may elucidate distinct patterns of brain function and cognition that could inform prevention and intervention.

AB - The growing literature on cognitive deficits in depression is considered in light of regional brain activity as well as comorbid anxiety and life stressors. Cognitive impairments associated with depression are reviewed, with an emphasis on various aspects of executive function such as memory, attention, and problem-solving. These deficits are related to patterns of brain activity observed in prefrontal, anterior cingulate, and parietal cortices, as well as in subcortical regions. Evidence for the largely unexplored role of environmental stressors in depression and their impact on cognition and brain function is also examined, and promising avenues of additional research are noted. In addition to promoting interdisciplinary research, systematically assessing variables such as cognitive performance, comorbid anxiety, and relevant stressors may elucidate distinct patterns of brain function and cognition that could inform prevention and intervention.

KW - Anterior cingulate cortex

KW - Anxiety

KW - Depression

KW - Executive function

KW - Prefrontal cortex

KW - Stress

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Cognitive deficits in depression and functional specificity of regional brain activity

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