@article{ac5d8bf431ff4928b7f7d9dd38f95669,
title = "Cobalt-Catalyzed and Lewis Acid-Assisted Nitrile Hydrogenation to Primary Amines: A Combined Effort",
abstract = "The selective hydrogenation of nitriles to primary amines using a bench-stable cobalt precatalyst under 4 atm of H2 is reported herein. The catalyst precursor was reduced in situ using NaHBEt3, and the resulting Lewis acid formed, BEt3, was found to be integral to the observed catalysis. Mechanistic insights gleaned from para-hydrogen induced polarization (PHIP) transfer NMR studies revealed that the pairwise hydrogenation of nitriles proceeded through a Co(I/III) redox process.",
author = "Kenan Tokmic and Jackson, {Bailey J.} and Andrea Salazar and Woods, {Toby J.} and Fout, {Alison R.}",
note = "Funding Information: The authors thank the NSF for financial support with a CAREER award (1351961) to A.R.F. A.R.F. is a Sloan Research Fellow and a Camille Dreyfus Teacher-Scholar. The authors thank Charles R. Markus and Prof. Benjamin J. McCall for use of the p-H2 generator; Charles R. Markus has been supported in part by an NSF award (CHE 12-13811) and a NASA award (NNX13AE62G) to PI Prof. Benjamin J. McCall. Finally, we thank Dr. Lingyang Zhu for help with the PHIP NMR studies. Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",
year = "2017",
month = sep,
day = "27",
doi = "10.1021/jacs.7b07368",
language = "English (US)",
volume = "139",
pages = "13554--13561",
journal = "Journal of the American Chemical Society",
issn = "0002-7863",
publisher = "American Chemical Society",
number = "38",
}