Coatings for biodegradable magnesium-based supports for therapy of vascular disease: A general view

Mónica Echeverry-Rendon, Jean Paul Allain, Sara M. Robledo, Felix Echeverria, Martin C. Harmsen

Research output: Contribution to journalReview article

Abstract

Metal stents are used as base material for fabrication of medical devices to support and improve the quality of life of patients with cardiovascular diseases such as arterial stenoses. Permanently present implants may induce responses that resemble adverse wound healing that compromise tissue function. A similar process namely restenosis, frequently may occur after the use of this kind of implants. However, the use of non-permanent, resorbable stents are a promising option to avoid this problem. The advantage of these implants is that they can degraded upon vascular repair. The most common metal used for this application, is magnesium (Mg) which is an interesting material due its biological properties and because it is an essential element for human life. However, Mg-based resorbable biomaterial have some restrictions in clinical applications because its corrosion resistance, and mechanical properties. As solutions of this problem, the material can be modified in its composition (Mg-based alloys) or by surface treatments. This review shows and discusses recent challenges in the improvement of Mg-based biomaterials to be used to treat vascular disease and novel approaches at design-based biomaterials engineering of the same. Design-based methodologies are introduced and discussed in the context of balancing multi-functional properties against adaptation to the complex extreme in vivo environment. Traditional alloying approaches of Mg-based biomaterials are also discussed in the context of corrosion resistance controlled by surface modification strategies including conversion techniques: physicochemical or electrochemical transformation such as anodization, plasma and electrophoretic deposition.

Original languageEnglish (US)
Pages (from-to)150-163
Number of pages14
JournalMaterials Science and Engineering C
Volume102
DOIs
StatePublished - Sep 2019

Fingerprint

Magnesium
magnesium
Biocompatible Materials
therapy
Biomaterials
coatings
Coatings
Stents
corrosion resistance
Corrosion resistance
Surface treatment
Metals
wound healing
surface treatment
Alloying
metals
alloying
constrictions
Repair
engineering

Keywords

  • Biocorrosion
  • Biodegradation
  • Cardiovascular disease
  • Magnesium
  • Stent
  • Surface modification

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Coatings for biodegradable magnesium-based supports for therapy of vascular disease : A general view. / Echeverry-Rendon, Mónica; Allain, Jean Paul; Robledo, Sara M.; Echeverria, Felix; Harmsen, Martin C.

In: Materials Science and Engineering C, Vol. 102, 09.2019, p. 150-163.

Research output: Contribution to journalReview article

Echeverry-Rendon, Mónica ; Allain, Jean Paul ; Robledo, Sara M. ; Echeverria, Felix ; Harmsen, Martin C. / Coatings for biodegradable magnesium-based supports for therapy of vascular disease : A general view. In: Materials Science and Engineering C. 2019 ; Vol. 102. pp. 150-163.
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