Coated substrates employing oriented layers of mutant heme proteins and methods of making and using same

Jill M Olinger (Inventor), Stephen G Sligar (Inventor), Mark A McLean (Inventor), Paul W Bohn (Inventor), Patrick Stayton (Inventor)

Research output: Patent

Abstract

The present invention is directed to coated substrates having a coating of biological macromolecules, preferably proteins, which are capable of being immobilized on a substrate surface and have a marker. These proteins usually are mutant proteins obtained by mutagenesis of the gene encoding a random positioning protein. When a mutant protein molecule is immobilized on the substrate, the marker of the mutant protein molecule is in a select spatial relationship with both the substrate and the markers of adjacent protein molecules. A substrate coated with an oriented layer of the mutant proteins exhibits improved or different properties when compared to a substrate having a randomly positioned layer of proteins thereon.
Original languageEnglish (US)
U.S. patent number5466589
StatePublished - Nov 14 1995

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