Co-occurring anxiety influences patterns of brain activity in depression

Anna S. Engels, Wendy Heller, Jeffrey M. Spielberg, Stacie L. Warren, Bradley P. Sutton, Marie T. Banich, Gregory A. Miller

Research output: Contribution to journalArticle

Abstract

Brain activation associated with anhedonic depression and co-occurring anxious arousal and anxious apprehension was measured by fMRI during performance of an emotion word Stroop task. Consistent with EEG findings, depression was associated with rightward frontal lateralization in the dorsolateral prefrontal cortex (DLPFC), but only when anxious arousal was elevated and anxious apprehension was low. Activity in the right inferior frontal gyrus (IFG) was also reduced for depression under the same conditions. In contrast, depression was associated with more activity in the anterior cingulate cortex (dorsal ACC and rostral ACC) and the bilateral amygdala. Results imply that depression, particularly when accompanied by anxious arousal, may result in a failure to implement top-down processing by appropriate brain regions (left DLPFC, right IFG) due to increased activation in regions associated with responding to emotionally salient information (right DLPFC, amygdala).

Original languageEnglish (US)
Pages (from-to)141-156
Number of pages16
JournalCognitive, Affective and Behavioral Neuroscience
Volume10
Issue number1
DOIs
StatePublished - Mar 1 2010

Fingerprint

Prefrontal Cortex
Anxiety
Depression
Arousal
Brain
Amygdala
Gyrus Cinguli
Electroencephalography
Emotions
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Co-occurring anxiety influences patterns of brain activity in depression. / Engels, Anna S.; Heller, Wendy; Spielberg, Jeffrey M.; Warren, Stacie L.; Sutton, Bradley P.; Banich, Marie T.; Miller, Gregory A.

In: Cognitive, Affective and Behavioral Neuroscience, Vol. 10, No. 1, 01.03.2010, p. 141-156.

Research output: Contribution to journalArticle

Engels, Anna S. ; Heller, Wendy ; Spielberg, Jeffrey M. ; Warren, Stacie L. ; Sutton, Bradley P. ; Banich, Marie T. ; Miller, Gregory A. / Co-occurring anxiety influences patterns of brain activity in depression. In: Cognitive, Affective and Behavioral Neuroscience. 2010 ; Vol. 10, No. 1. pp. 141-156.
@article{3b551a9fae174615a91ecfb2e6fc5deb,
title = "Co-occurring anxiety influences patterns of brain activity in depression",
abstract = "Brain activation associated with anhedonic depression and co-occurring anxious arousal and anxious apprehension was measured by fMRI during performance of an emotion word Stroop task. Consistent with EEG findings, depression was associated with rightward frontal lateralization in the dorsolateral prefrontal cortex (DLPFC), but only when anxious arousal was elevated and anxious apprehension was low. Activity in the right inferior frontal gyrus (IFG) was also reduced for depression under the same conditions. In contrast, depression was associated with more activity in the anterior cingulate cortex (dorsal ACC and rostral ACC) and the bilateral amygdala. Results imply that depression, particularly when accompanied by anxious arousal, may result in a failure to implement top-down processing by appropriate brain regions (left DLPFC, right IFG) due to increased activation in regions associated with responding to emotionally salient information (right DLPFC, amygdala).",
author = "Engels, {Anna S.} and Wendy Heller and Spielberg, {Jeffrey M.} and Warren, {Stacie L.} and Sutton, {Bradley P.} and Banich, {Marie T.} and Miller, {Gregory A.}",
year = "2010",
month = "3",
day = "1",
doi = "10.3758/CABN.10.1.141",
language = "English (US)",
volume = "10",
pages = "141--156",
journal = "Cognitive, Affective and Behavioral Neuroscience",
issn = "1530-7026",
publisher = "Springer New York",
number = "1",

}

TY - JOUR

T1 - Co-occurring anxiety influences patterns of brain activity in depression

AU - Engels, Anna S.

AU - Heller, Wendy

AU - Spielberg, Jeffrey M.

AU - Warren, Stacie L.

AU - Sutton, Bradley P.

AU - Banich, Marie T.

AU - Miller, Gregory A.

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Brain activation associated with anhedonic depression and co-occurring anxious arousal and anxious apprehension was measured by fMRI during performance of an emotion word Stroop task. Consistent with EEG findings, depression was associated with rightward frontal lateralization in the dorsolateral prefrontal cortex (DLPFC), but only when anxious arousal was elevated and anxious apprehension was low. Activity in the right inferior frontal gyrus (IFG) was also reduced for depression under the same conditions. In contrast, depression was associated with more activity in the anterior cingulate cortex (dorsal ACC and rostral ACC) and the bilateral amygdala. Results imply that depression, particularly when accompanied by anxious arousal, may result in a failure to implement top-down processing by appropriate brain regions (left DLPFC, right IFG) due to increased activation in regions associated with responding to emotionally salient information (right DLPFC, amygdala).

AB - Brain activation associated with anhedonic depression and co-occurring anxious arousal and anxious apprehension was measured by fMRI during performance of an emotion word Stroop task. Consistent with EEG findings, depression was associated with rightward frontal lateralization in the dorsolateral prefrontal cortex (DLPFC), but only when anxious arousal was elevated and anxious apprehension was low. Activity in the right inferior frontal gyrus (IFG) was also reduced for depression under the same conditions. In contrast, depression was associated with more activity in the anterior cingulate cortex (dorsal ACC and rostral ACC) and the bilateral amygdala. Results imply that depression, particularly when accompanied by anxious arousal, may result in a failure to implement top-down processing by appropriate brain regions (left DLPFC, right IFG) due to increased activation in regions associated with responding to emotionally salient information (right DLPFC, amygdala).

UR - http://www.scopus.com/inward/record.url?scp=77953119286&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953119286&partnerID=8YFLogxK

U2 - 10.3758/CABN.10.1.141

DO - 10.3758/CABN.10.1.141

M3 - Article

C2 - 20233962

AN - SCOPUS:77953119286

VL - 10

SP - 141

EP - 156

JO - Cognitive, Affective and Behavioral Neuroscience

JF - Cognitive, Affective and Behavioral Neuroscience

SN - 1530-7026

IS - 1

ER -