Clotting activity of polyphosphate-functionalized silica Nanoparticles

Damien Kudela; Stephanie A. Smith; Anna May-Masnou; Gary B. Braun; Alessia Pallaoro; Chi K. Nguyen; Tracy T. Chuong; Sara Nownes; Riley Allen; Nicholas R. Parker; Hooman H. Rashidi; James H. Morrissey; Galen D. Stucky

doi:10.1002/anie.201409639

Clotting activity of polyphosphate-functionalized silica Nanoparticles

Damien Kudela, Stephanie A. Smith, Anna May-Masnou, Gary B. Braun, Alessia Pallaoro, Chi K. Nguyen, Tracy T. Chuong, Sara Nownes, Riley Allen, Nicholas R. Parker, Hooman H. Rashidi, James H. Morrissey, Galen D. Stucky

Research output: Contribution to journal › Article › peer-review

Abstract

We present a silica nanoparticle (SNP) functionalized with polyphosphate (polyP) that accelerates the natural clotting process of the body. SNPs initiate the contact pathway of the blood-clotting system; short-chain polyP accelerates the common pathway by the rapid formation of thrombin, which enhances the overall blood-clotting system, both by accelerating fibrin generation and by facilitating the regulatory anticoagulation mechanisms essential for hemostasis. Analysis of the clotting properties of bare SNPs, bare polyP, and polyP-functionalized SNPs in plasma demonstrated that the attachment of polyP to SNPs to form polyP-SNPs creates a substantially enhanced synergistic effect that lowers clotting time and increases thrombin production at low concentrations. PolyP-SNP even retains its clotting function at ambient temperature. The polyP-SNP system has the potential to significantly improve trauma-treatment protocols and outcomes in hospital and prehospital settings.

Original language	English (US)
Pages (from-to)	4018-4022
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	54
Issue number	13
DOIs	https://doi.org/10.1002/anie.201409639
State	Published - Mar 23 2015
Externally published	Yes

Keywords

hemorrhage
nanoparticles
polyphosphates
silicates
trauma

ASJC Scopus subject areas

Catalysis
General Chemistry

Online availability

10.1002/anie.201409639

Library availability

Discover UIUC Full Text

Cite this

@article{ef306547e4ee46abbf6b9c2097d127ad,

title = "Clotting activity of polyphosphate-functionalized silica Nanoparticles",

abstract = "We present a silica nanoparticle (SNP) functionalized with polyphosphate (polyP) that accelerates the natural clotting process of the body. SNPs initiate the contact pathway of the blood-clotting system; short-chain polyP accelerates the common pathway by the rapid formation of thrombin, which enhances the overall blood-clotting system, both by accelerating fibrin generation and by facilitating the regulatory anticoagulation mechanisms essential for hemostasis. Analysis of the clotting properties of bare SNPs, bare polyP, and polyP-functionalized SNPs in plasma demonstrated that the attachment of polyP to SNPs to form polyP-SNPs creates a substantially enhanced synergistic effect that lowers clotting time and increases thrombin production at low concentrations. PolyP-SNP even retains its clotting function at ambient temperature. The polyP-SNP system has the potential to significantly improve trauma-treatment protocols and outcomes in hospital and prehospital settings.",

keywords = "hemorrhage, nanoparticles, polyphosphates, silicates, trauma",

author = "Damien Kudela and Smith, {Stephanie A.} and Anna May-Masnou and Braun, {Gary B.} and Alessia Pallaoro and Nguyen, {Chi K.} and Chuong, {Tracy T.} and Sara Nownes and Riley Allen and Parker, {Nicholas R.} and Rashidi, {Hooman H.} and Morrissey, {James H.} and Stucky, {Galen D.}",

note = "Publisher Copyright: {\textcopyright} 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2015",

month = mar,

day = "23",

doi = "10.1002/anie.201409639",

language = "English (US)",

volume = "54",

pages = "4018--4022",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley & Sons, Ltd.",

number = "13",

}

TY - JOUR

T1 - Clotting activity of polyphosphate-functionalized silica Nanoparticles

AU - Kudela, Damien

AU - Smith, Stephanie A.

AU - May-Masnou, Anna

AU - Braun, Gary B.

AU - Pallaoro, Alessia

AU - Nguyen, Chi K.

AU - Chuong, Tracy T.

AU - Nownes, Sara

AU - Allen, Riley

AU - Parker, Nicholas R.

AU - Rashidi, Hooman H.

AU - Morrissey, James H.

AU - Stucky, Galen D.

PY - 2015/3/23

Y1 - 2015/3/23

N2 - We present a silica nanoparticle (SNP) functionalized with polyphosphate (polyP) that accelerates the natural clotting process of the body. SNPs initiate the contact pathway of the blood-clotting system; short-chain polyP accelerates the common pathway by the rapid formation of thrombin, which enhances the overall blood-clotting system, both by accelerating fibrin generation and by facilitating the regulatory anticoagulation mechanisms essential for hemostasis. Analysis of the clotting properties of bare SNPs, bare polyP, and polyP-functionalized SNPs in plasma demonstrated that the attachment of polyP to SNPs to form polyP-SNPs creates a substantially enhanced synergistic effect that lowers clotting time and increases thrombin production at low concentrations. PolyP-SNP even retains its clotting function at ambient temperature. The polyP-SNP system has the potential to significantly improve trauma-treatment protocols and outcomes in hospital and prehospital settings.

AB - We present a silica nanoparticle (SNP) functionalized with polyphosphate (polyP) that accelerates the natural clotting process of the body. SNPs initiate the contact pathway of the blood-clotting system; short-chain polyP accelerates the common pathway by the rapid formation of thrombin, which enhances the overall blood-clotting system, both by accelerating fibrin generation and by facilitating the regulatory anticoagulation mechanisms essential for hemostasis. Analysis of the clotting properties of bare SNPs, bare polyP, and polyP-functionalized SNPs in plasma demonstrated that the attachment of polyP to SNPs to form polyP-SNPs creates a substantially enhanced synergistic effect that lowers clotting time and increases thrombin production at low concentrations. PolyP-SNP even retains its clotting function at ambient temperature. The polyP-SNP system has the potential to significantly improve trauma-treatment protocols and outcomes in hospital and prehospital settings.

KW - hemorrhage

KW - nanoparticles

KW - polyphosphates

KW - silicates

KW - trauma

UR - http://www.scopus.com/inward/record.url?scp=84922496065&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922496065&partnerID=8YFLogxK

U2 - 10.1002/anie.201409639

DO - 10.1002/anie.201409639

M3 - Article

AN - SCOPUS:84922496065

SN - 1433-7851

VL - 54

SP - 4018

EP - 4022

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 13

ER -

Clotting activity of polyphosphate-functionalized silica Nanoparticles

Abstract

Keywords

ASJC Scopus subject areas

Online availability

Library availability

Related links

Fingerprint

Cite this