Clostridium: Clostridium acetobutylicum

H. Janssen, Y. Wang, H. P. Blaschek

Research output: Chapter in Book/Report/Conference proceedingChapter


Clostridium acetobutylicum belongs to a group of Gram-positive and endospore forming anaerobes and is considered to be a model organism for solventogenic clostridia due to its acetone-butanol-ethanol (ABE) fermentation metabolism. This chapter focuses on the physiology of the biphasic fermentative metabolism of C. acetobutylicum, the history of the ABE fermentation, and industrial applications during the past century. Different approaches to improving solvent production and overcoming solvent toxicity utilizing genetic tools developed over the past 20 years are also discussed.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Food Microbiology
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages9
ISBN (Electronic)9780123847331
ISBN (Print)9780123847300
StatePublished - Apr 2 2014


  • ABE fermentation
  • Acetate
  • Acetone
  • Acidogenesis
  • Butanol
  • Butanol tolerance
  • Butyrate
  • Clostridia
  • Clostridium acetobutylicum
  • Genetic engineering
  • Product recovery
  • Solventogenesis

ASJC Scopus subject areas

  • General Medicine


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