Close encounters between active genes in the nucleus

Chien Hui Chuang, Andrew S. Belmont

Research output: Contribution to journalShort surveypeer-review


A recent paper demonstrates that coregulated genes on different chromosomes show surprisingly high frequencies of colocalization within the nucleus; this complements similar results found previously for genes localized tens of megabases apart on a single chromosome. Colocalization could be related to the earlier observation of active genes associating with foci where RNA polymerase II is concentrated.

Original languageEnglish (US)
Article number237
JournalGenome biology
Issue number11
StatePublished - 2005

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Cell Biology


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