Abstract
By serological screening of a breast tumor cDNA library we have identified a novel human gene, tnkl, encoding an ankyrin-related protein with a high degree of similarity to tankyrase, the poly(ADP-ribose)polymerase associated with human telomeres (Smith et al, Science 282: 1484). The tnkl gene maps to chromosome 10, while the tnks gene encoding tankyrase is located on chromosome 8. The predicted 1166-aa protein product of the tnkl gene is 78% identical to human tankyrase and 62% to a putative D. melanogaster protein. Since the proteins have essentially identical domain structures, the corresponding genes form a distinct gene family. The possible link between TNKL and cancer justifies its further functional analysis.
Original language | English (US) |
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Pages (from-to) | 52-55 |
Number of pages | 4 |
Journal | Genes and Immunity |
Volume | 2 |
Issue number | 1 |
DOIs | |
State | Published - Feb 2001 |
Keywords
- Ankyrin
- Antibodies
- SEREX
- Tankyrase
- Telomeres
ASJC Scopus subject areas
- Immunology
- Genetics
- Genetics(clinical)