Cloning and characterization of TNKL, a member of tankyrase gene family

A. N. Kuimov; D. V. Kuprash; V. N. Petrov; K. K. Vdovichenko; M. J. Scanlan; C. V. Jongeneel; Ma Lagarkova; S. A. Nedospasov

doi:10.1038/sj.gene.6363722

Cloning and characterization of TNKL, a member of tankyrase gene family

A. N. Kuimov, D. V. Kuprash, V. N. Petrov, K. K. Vdovichenko, M. J. Scanlan, C. V. Jongeneel, Ma Lagarkova, S. A. Nedospasov

National Center for Supercomputing Applications (NCSA)

Research output: Contribution to journal › Article › peer-review

Abstract

By serological screening of a breast tumor cDNA library we have identified a novel human gene, tnkl, encoding an ankyrin-related protein with a high degree of similarity to tankyrase, the poly(ADP-ribose)polymerase associated with human telomeres (Smith et al, Science 282: 1484). The tnkl gene maps to chromosome 10, while the tnks gene encoding tankyrase is located on chromosome 8. The predicted 1166-aa protein product of the tnkl gene is 78% identical to human tankyrase and 62% to a putative D. melanogaster protein. Since the proteins have essentially identical domain structures, the corresponding genes form a distinct gene family. The possible link between TNKL and cancer justifies its further functional analysis.

Original language	English (US)
Pages (from-to)	52-55
Number of pages	4
Journal	Genes and Immunity
Volume	2
Issue number	1
DOIs	https://doi.org/10.1038/sj.gene.6363722
State	Published - Feb 2001

Keywords

Ankyrin
Antibodies
SEREX
Tankyrase
Telomeres

ASJC Scopus subject areas

Immunology
Genetics
Genetics(clinical)

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title = "Cloning and characterization of TNKL, a member of tankyrase gene family",

abstract = "By serological screening of a breast tumor cDNA library we have identified a novel human gene, tnkl, encoding an ankyrin-related protein with a high degree of similarity to tankyrase, the poly(ADP-ribose)polymerase associated with human telomeres (Smith et al, Science 282: 1484). The tnkl gene maps to chromosome 10, while the tnks gene encoding tankyrase is located on chromosome 8. The predicted 1166-aa protein product of the tnkl gene is 78% identical to human tankyrase and 62% to a putative D. melanogaster protein. Since the proteins have essentially identical domain structures, the corresponding genes form a distinct gene family. The possible link between TNKL and cancer justifies its further functional analysis.",

keywords = "Ankyrin, Antibodies, SEREX, Tankyrase, Telomeres",

author = "Kuimov, {A. N.} and Kuprash, {D. V.} and Petrov, {V. N.} and Vdovichenko, {K. K.} and Scanlan, {M. J.} and Jongeneel, {C. V.} and Ma Lagarkova and Nedospasov, {S. A.}",

note = "Funding Information: This project has been funded by the Ludwig Institute for Cancer Research, and by grants 00-04-48300 (ANK) and 98-04-49031 (MAL) from the Russian Foundation for Basic Research.",

year = "2001",

month = feb,

doi = "10.1038/sj.gene.6363722",

language = "English (US)",

volume = "2",

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journal = "Genes and Immunity",

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AU - Kuimov, A. N.

AU - Kuprash, D. V.

AU - Petrov, V. N.

AU - Vdovichenko, K. K.

AU - Scanlan, M. J.

AU - Jongeneel, C. V.

AU - Lagarkova, Ma

AU - Nedospasov, S. A.

N1 - Funding Information: This project has been funded by the Ludwig Institute for Cancer Research, and by grants 00-04-48300 (ANK) and 98-04-49031 (MAL) from the Russian Foundation for Basic Research.

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N2 - By serological screening of a breast tumor cDNA library we have identified a novel human gene, tnkl, encoding an ankyrin-related protein with a high degree of similarity to tankyrase, the poly(ADP-ribose)polymerase associated with human telomeres (Smith et al, Science 282: 1484). The tnkl gene maps to chromosome 10, while the tnks gene encoding tankyrase is located on chromosome 8. The predicted 1166-aa protein product of the tnkl gene is 78% identical to human tankyrase and 62% to a putative D. melanogaster protein. Since the proteins have essentially identical domain structures, the corresponding genes form a distinct gene family. The possible link between TNKL and cancer justifies its further functional analysis.

AB - By serological screening of a breast tumor cDNA library we have identified a novel human gene, tnkl, encoding an ankyrin-related protein with a high degree of similarity to tankyrase, the poly(ADP-ribose)polymerase associated with human telomeres (Smith et al, Science 282: 1484). The tnkl gene maps to chromosome 10, while the tnks gene encoding tankyrase is located on chromosome 8. The predicted 1166-aa protein product of the tnkl gene is 78% identical to human tankyrase and 62% to a putative D. melanogaster protein. Since the proteins have essentially identical domain structures, the corresponding genes form a distinct gene family. The possible link between TNKL and cancer justifies its further functional analysis.

KW - Ankyrin

KW - Antibodies

KW - SEREX

KW - Tankyrase

KW - Telomeres

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Cloning and characterization of TNKL, a member of tankyrase gene family

Abstract

Keywords

ASJC Scopus subject areas

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