Cloning and characterization of TNKL, a member of tankyrase gene family

A. N. Kuimov, D. V. Kuprash, V. N. Petrov, K. K. Vdovichenko, M. J. Scanlan, C. V. Jongeneel, Ma Lagarkova, S. A. Nedospasov

Research output: Contribution to journalArticlepeer-review

Abstract

By serological screening of a breast tumor cDNA library we have identified a novel human gene, tnkl, encoding an ankyrin-related protein with a high degree of similarity to tankyrase, the poly(ADP-ribose)polymerase associated with human telomeres (Smith et al, Science 282: 1484). The tnkl gene maps to chromosome 10, while the tnks gene encoding tankyrase is located on chromosome 8. The predicted 1166-aa protein product of the tnkl gene is 78% identical to human tankyrase and 62% to a putative D. melanogaster protein. Since the proteins have essentially identical domain structures, the corresponding genes form a distinct gene family. The possible link between TNKL and cancer justifies its further functional analysis.

Original languageEnglish (US)
Pages (from-to)52-55
Number of pages4
JournalGenes and Immunity
Volume2
Issue number1
DOIs
StatePublished - Feb 2001

Keywords

  • Ankyrin
  • Antibodies
  • SEREX
  • Tankyrase
  • Telomeres

ASJC Scopus subject areas

  • Immunology
  • Genetics
  • Genetics(clinical)

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