Clinical Significance of Lateral Pedicle Screw Malposition in Lumbar Spine Fusion

Taryn E. Leroy, Isabel C. Smith, David H. Kim, Samuel W. Golenbock, Kevin C. Baker, Paul M. Arnold, Rick C. Sasso, Daniel K. Park, Jeffrey S. Fischgrund, Qasim H. Zaidi, Raymond W. Hwang

Research output: Contribution to journalArticlepeer-review


Study Design: Retrospective cohort study. Objective: Our objective was to determine whether lateral pedicle screw breach affects fusion rates and patient-reported outcomes in lumbar fusion surgery. Summary of Background Data: Although lateral pedicle screw malposition is considered relatively benign, few studies have focused specifically on clinical outcomes or fusion rates associated with lateral screw malposition. Methods: Twelve-month postoperative computed tomography scans were reviewed for lateral breach, severity of breach, and fusion status. Patients with lateral breach were compared with patients with no breach. Outcome measures included Numerical Pain Rating Scale for back and leg pain, Oswestry Disability Index, and SF-36 physical function (SF-36 PF). Multivariable linear and logistic regression and were adjusted for age, procedure, level, and/or baseline pain score. Results: Forty-five patients (31%) demonstrated 1 or more lateral breaches as compared with 99 patients without breach. After adjusting for baseline scores and fusion level, patients with 2 or more screw breaches experienced SF-36 PF score improvements that were 3.43 points less (P=0.016) than patients with no lateral breach. After adjusting for baseline Numerical Pain Rating Scale, there was also a significant decrease in the odds of achieving minimally clinical important difference in back pain relief in these patients. There was no observed effect of lateral breach on the odds of successful fusion. Conclusions: The current study did not observe an association between laterally malpositioned pedicle screws and nonunion. However, results are consistent with a negative effect on SF-36 PF scores and self-reported back pain at 12 months.

Original languageEnglish (US)
Pages (from-to)E258-E262
JournalClinical spine surgery
Issue number6
StatePublished - Jul 1 2023
Externally publishedYes


  • TLIF
  • breach
  • fusion rate
  • lumbar fusion
  • malposition
  • patient-reported outcomes
  • pedicle screw

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Orthopedics and Sports Medicine


Dive into the research topics of 'Clinical Significance of Lateral Pedicle Screw Malposition in Lumbar Spine Fusion'. Together they form a unique fingerprint.

Cite this