Clinical implication of Meissner's corpuscles

Jose A. Vega, Alfonso López-Muñiz, Marta G. Calavia, Olivia García-Suárez, Juan Cobo, Jesús Otero, Oscar Arias-Carrión, Pablo Pérez-Piñera, Manuel Menéndez-González

Research output: Contribution to journalReview article

Abstract

During the last decade skin biopsy has been confirmed as a tool to provide diagnostic information on some peripheral neuropathies. Most studies were focused on intraepithelial nerve fibers and few studies have investigated large myelinated fibers or whether corpuscles in human skin change quantitatively or qualitatively in pathologies of the peripheral or central nervous system. The main objective of this article is to provide a comprehensive review of Meissner's corpuscles including their distribution, density and age changes, development, molecular composition, cellular anatomy and physiology. We also describe their involvement in several pathologies and suggest including this dermal structure in the routine study of skin biopsies, looking for changes to be used as potential markers for several disorders. Finally the article draws the main aspects of how to study Meissner's corpuscles in skin biopsies and gives a view on future perspectives for implementing their use in clinical practice.

Original languageEnglish (US)
Pages (from-to)856-868
Number of pages13
JournalCNS and Neurological Disorders - Drug Targets
Volume11
Issue number7
DOIs
StatePublished - Dec 1 2012

Keywords

  • Guidelines
  • Meissner's corpuscles
  • Neuropathy
  • Skin biopsy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology

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    Vega, J. A., López-Muñiz, A., Calavia, M. G., García-Suárez, O., Cobo, J., Otero, J., Arias-Carrión, O., Pérez-Piñera, P., & Menéndez-González, M. (2012). Clinical implication of Meissner's corpuscles. CNS and Neurological Disorders - Drug Targets, 11(7), 856-868. https://doi.org/10.2174/1871527311201070856