Clinical correlations of transcriptional profile in patients infected with avian influenza H7N9 virus

Wenda Guan, Zifeng Yang, Nicholas C. Wu, Horace H.Y. Lee, Yimin Li, Wenxin Jiang, Lihan Shen, Douglas C. Wu, Rongchang Chen, Nanshan Zhong, Ian A. Wilson, Malik Peiris, Chris K.P. Mok

Research output: Contribution to journalArticlepeer-review


Background. Avian influenza A (H7N9) viruses emerged in China in 2013 and caused zoonotic disease associated with a case-fatality ratio of over 30%. Transcriptional profiles in peripheral blood reflect host responses and can help to elucidate disease pathogenesis. Methods. We correlated serial blood transcriptomic profiles of patients with avian influenza A (H7N9) virus infection and determined the biological significances from the analysis. Results. We found that specific gene expression profiles in the blood were strongly correlated with the Pao2/Fio2 ratio and viral load in the lower respiratory tract. Cell cycle and leukocyte-related immunity were activated at the acute stage of the infection while T-cell functions and various metabolic processes were associated with the recovery phase of the illness. A transition from systemic innate to adaptive immunity was found. Conclusions. We developed a novel approach for transcriptomic analysis to identify key host responses that were strongly correlated with specific clinical and virologic parameters in patients with H7N9 infection.

Original languageEnglish (US)
Pages (from-to)1238-1248
Number of pages11
JournalJournal of Infectious Diseases
Issue number8
StatePublished - Sep 8 2018
Externally publishedYes


  • Avian influenza
  • H7N9
  • Pao/ Fio
  • Transcriptomic

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


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