@article{bd2bde832d6444e8bdf40fe11b2770b1,
title = "Clinical correlations of transcriptional profile in patients infected with avian influenza H7N9 virus",
abstract = "Background. Avian influenza A (H7N9) viruses emerged in China in 2013 and caused zoonotic disease associated with a case-fatality ratio of over 30%. Transcriptional profiles in peripheral blood reflect host responses and can help to elucidate disease pathogenesis. Methods. We correlated serial blood transcriptomic profiles of patients with avian influenza A (H7N9) virus infection and determined the biological significances from the analysis. Results. We found that specific gene expression profiles in the blood were strongly correlated with the Pao2/Fio2 ratio and viral load in the lower respiratory tract. Cell cycle and leukocyte-related immunity were activated at the acute stage of the infection while T-cell functions and various metabolic processes were associated with the recovery phase of the illness. A transition from systemic innate to adaptive immunity was found. Conclusions. We developed a novel approach for transcriptomic analysis to identify key host responses that were strongly correlated with specific clinical and virologic parameters in patients with H7N9 infection.",
keywords = "Avian influenza, H7N9, Pao/ Fio, Transcriptomic",
author = "Wenda Guan and Zifeng Yang and Wu, {Nicholas C.} and Lee, {Horace H.Y.} and Yimin Li and Wenxin Jiang and Lihan Shen and Wu, {Douglas C.} and Rongchang Chen and Nanshan Zhong and Wilson, {Ian A.} and Malik Peiris and Mok, {Chris K.P.}",
note = "Funding Information: Financial support. This work was supported by the National Natural Science Foundation of China (grant number 81761128014); Science Research Project of the Guangdong Province (grant number 2016A050503047); Municipal Science and Technology Bureau Foundation of Guangzhou (grant number 2014Y2-00031); Research Grants Council of the Hong Kong Special Administrative Region, China, through the Theme Based Research Scheme (reference T11-705/14N); National Institutes of Health (grant number R56 AI127371); and a Croucher Foundation Fellowship (N.C.W.). Funding Information: We would like to thank all the clinical and research staff who contributed to this study. This work was supported by the National Natural Science Foundation of China (grant number 81761128014); Science Research Project of the Guangdong Province (grant number 2016A050503047); Municipal Science and Technology Bureau Foundation of Guangzhou (grant number 2014Y2-00031); Research Grants Council of the Hong Kong Special Administrative Region, China, through the Theme Based Research Scheme (reference T11-705/14N); National Institutes of Health (grant number R56 AI127371); and a Croucher Foundation Fellowship (N.C.W.). Publisher Copyright: {\textcopyright} The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America.",
year = "2018",
month = sep,
day = "8",
doi = "10.1093/infdis/jiy317",
language = "English (US)",
volume = "218",
pages = "1238--1248",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "8",
}