TY - JOUR
T1 - Clinical and immunohistochemical characterization of thymic lymphosarcoma in a heifer
AU - Alexander, Andrew N.
AU - Constable, Peter D.
AU - Meier, William A.
AU - French, Richard A.
AU - Morin, Dawn E.
AU - Lowry, Jennifer E.
AU - Hoffman, Walter E.
PY - 1996
Y1 - 1996
N2 - A 2-year-old Holstein heifer with a swollen brisket, jugular vein distention, muffled heart sounds, tachycardia, and free gas bloat was examined. Thymic lymphosarcoma was suspected based on a negative agar gel immunodiffusion test for bovine leukemia virus, presence of atypical lymphocytes in pleural fluid, and detection of a mass in the thoracic inlet. Right-sided cardiac catheterization was performed, and markedly increased jugular venous pressures (41 mm Hg) with a pressure gradient of 29 mm Hg immediately cranial to the heart indicated constriction of the cranial vena cava. Immunohistochemical staining of formalin fixed, paraffin-embedded tissue sections of the tumor using a rabbit anti-human T cell, CD3 polyclonal antibody confirmed that the neoplastic lymphocytes were of thymic origin.
AB - A 2-year-old Holstein heifer with a swollen brisket, jugular vein distention, muffled heart sounds, tachycardia, and free gas bloat was examined. Thymic lymphosarcoma was suspected based on a negative agar gel immunodiffusion test for bovine leukemia virus, presence of atypical lymphocytes in pleural fluid, and detection of a mass in the thoracic inlet. Right-sided cardiac catheterization was performed, and markedly increased jugular venous pressures (41 mm Hg) with a pressure gradient of 29 mm Hg immediately cranial to the heart indicated constriction of the cranial vena cava. Immunohistochemical staining of formalin fixed, paraffin-embedded tissue sections of the tumor using a rabbit anti-human T cell, CD3 polyclonal antibody confirmed that the neoplastic lymphocytes were of thymic origin.
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U2 - 10.1111/j.1939-1676.1996.tb02062.x
DO - 10.1111/j.1939-1676.1996.tb02062.x
M3 - Article
C2 - 8819055
AN - SCOPUS:0030184835
SN - 0891-6640
VL - 10
SP - 275
EP - 278
JO - Journal of veterinary internal medicine
JF - Journal of veterinary internal medicine
IS - 4
ER -