Clinical and immunohistochemical characterization of thymic lymphosarcoma in a heifer

Andrew N. Alexander, Peter D. Constable, William A. Meier, Richard A. French, Dawn E. Morin, Jennifer E. Lowry, Walter E. Hoffman

Research output: Contribution to journalArticlepeer-review


A 2-year-old Holstein heifer with a swollen brisket, jugular vein distention, muffled heart sounds, tachycardia, and free gas bloat was examined. Thymic lymphosarcoma was suspected based on a negative agar gel immunodiffusion test for bovine leukemia virus, presence of atypical lymphocytes in pleural fluid, and detection of a mass in the thoracic inlet. Right-sided cardiac catheterization was performed, and markedly increased jugular venous pressures (41 mm Hg) with a pressure gradient of 29 mm Hg immediately cranial to the heart indicated constriction of the cranial vena cava. Immunohistochemical staining of formalin fixed, paraffin-embedded tissue sections of the tumor using a rabbit anti-human T cell, CD3 polyclonal antibody confirmed that the neoplastic lymphocytes were of thymic origin.

Original languageEnglish (US)
Pages (from-to)275-278
Number of pages4
JournalJournal of veterinary internal medicine
Issue number4
StatePublished - 1996

ASJC Scopus subject areas

  • veterinary(all)


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