Clinical and image-guided chorioretinal findings in long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency

Kiran Turaka, Joseph Shepard Bryan, Alan J. Gordon, Henry M. Kwong, Rahul Reddy, Michael Tsipursky, Clive H. Sell

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this study is to report clinical, optical coherence tomography (OCT), and fluorescein angiogram/indocyanine green angiography (FA/ICG) findings in patients with longchain 3-hydroxyacyl-coenzyme A dehydrogenase (LCHAD) enzyme deficiency in two siblings. A 13-year-old girl and her 14-year-old brother presented with progressive decrease in central vision. Clinically, there were blond-looking fundi, diffuse retinal pigment epithelial (RPE) disruption/atrophy in the macula and peripheral retina with choriocapillaris atrophy in both of them. OCT showed RPE irregularity and diffuse disruption of the RPE layer. FA/ICG imaging demonstrated transmitted choroidal fluorescence secondary to diffuse RPE atrophy with no evidence of leakage. Electroretinogram and electrooculogram findings were suggestive of primary abnormality of pigment epithelium. The boy died of cardiac/respiratory illness, whereas his sister is alive at the last follow-up. Abnormal chorioretinal findings in LCHAD patients should be carefully followed. Regular follow-up is recommended to monitor the ocular and systemic status.

Original languageEnglish (US)
Pages (from-to)565-567
Number of pages3
JournalJournal of Pediatric Endocrinology and Metabolism
Volume25
Issue number5-6
DOIs
StatePublished - Jun 1 2012
Externally publishedYes

Keywords

  • Fatty acid oxidation
  • Long-chain 3-hydroxyacylcoenzyme A dehydrogenase
  • Optical coherence tomography
  • Retina/RPE dysfunction

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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