Abstract
We functionalize nucleic acid nanostructures with click chemistry (for attachment of cargos) and a photocleavable linker (for release). We demonstrate cargo attachment using a fluorescein dye and release using UV trigger from an RNA three-way junction, a DNA star motif and a DNA tetrahedron. Such multifunctional nucleic acid nanostructures have potential in targeted drug delivery.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 9709-9712 |
| Number of pages | 4 |
| Journal | Chemical Communications |
| Volume | 55 |
| Issue number | 65 |
| DOIs | |
| State | Published - Aug 21 2019 |
| Externally published | Yes |
Keywords
- Animals
- Bacillus Phages/genetics
- Base Sequence
- Cattle
- Click Chemistry
- DNA/blood
- Drug Carriers/chemical synthesis
- Fluoresceins/chemistry
- Fluorescence
- Fluorescent Dyes/chemistry
- Nanostructures/chemistry
- Nucleic Acid Conformation
- RNA/blood
- Ultraviolet Rays
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Metals and Alloys
- Materials Chemistry
- Surfaces, Coatings and Films
- General Chemistry
- Catalysis