Classification Of Epigenetic Biomarkers And/or DNA Conformational Superstructures Via Use Of Atomically Thin Nanopores

Jean-Pierre Leburton (Inventor), Lav Raj Varshney (Inventor), Aditya Sarathy (Inventor), Nagendra B Athreya (Inventor)

Research output: Patent

Abstract

An apparatus comprising: a membrane with a first side, a second side, and a pore that extends through the membrane; a processing system including a processor; and a memory that stores executable instructions that, when executed by the processing system, facilitate performance of operations, the operations comprising: electronic sensing of an electrical characteristic associated with a translocation of a test DNA through the pore, resulting in a sensed electrical characteristic; comparing the sensed electrical characteristic with a plurality of reference electrical characteristics, wherein each of the plurality of reference electrical characteristics is associated with a respective one of a plurality of reference features, and wherein the comparing results in a comparison result; and determining, based upon the comparison result, with which of the plurality of reference features a feature of the test DNA corresponds. Additional embodiments are disclosed.
Original languageEnglish (US)
U.S. patent number11860123
StatePublished - Jan 2 2024

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