Classical swine fever virus inhibits nitric oxide production in infected macrophages

K. M. Zaffuto, M. E. Piccone, T. G. Burrage, C. A. Balinsky, G. R. Risatti, M. V. Borca, L. G. Holinka, D. L. Rock, Claudio L. Afonso

Research output: Contribution to journalArticlepeer-review


Classical swine fever virus (CSFV)-macrophage interactions during infection were analysed by examining macrophage transcriptional responses via microarray. Eleven genes had increased mRNA levels (>2.5-fold, P<0.05) in infected cell cultures, including arginase-1, an inhibitor of nitric oxide production, phosphoinositide 3-kinase, chemokine receptor 4 and interleukin-1β. Lower levels of nitric oxide and increased arginase activity were found in CSFV-infected macrophages. These changes in gene expression in macrophages suggest viral modulation of host expression to suppress nitric oxide production.

Original languageEnglish (US)
Pages (from-to)3007-3012
Number of pages6
JournalJournal of General Virology
Issue number11
StatePublished - Nov 2007

ASJC Scopus subject areas

  • Virology


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