Classical swine fever virus inhibits nitric oxide production in infected macrophages

K. M. Zaffuto; M. E. Piccone; T. G. Burrage; C. A. Balinsky; G. R. Risatti; M. V. Borca; L. G. Holinka; D. L. Rock; Claudio L. Afonso

doi:10.1099/vir.0.83042-0

Classical swine fever virus inhibits nitric oxide production in infected macrophages

K. M. Zaffuto, M. E. Piccone, T. G. Burrage, C. A. Balinsky, G. R. Risatti, M. V. Borca, L. G. Holinka, D. L. Rock, Claudio L. Afonso

Pathobiology

Research output: Contribution to journal › Article › peer-review

Abstract

Classical swine fever virus (CSFV)-macrophage interactions during infection were analysed by examining macrophage transcriptional responses via microarray. Eleven genes had increased mRNA levels (>2.5-fold, P<0.05) in infected cell cultures, including arginase-1, an inhibitor of nitric oxide production, phosphoinositide 3-kinase, chemokine receptor 4 and interleukin-1β. Lower levels of nitric oxide and increased arginase activity were found in CSFV-infected macrophages. These changes in gene expression in macrophages suggest viral modulation of host expression to suppress nitric oxide production.

Original language	English (US)
Pages (from-to)	3007-3012
Number of pages	6
Journal	Journal of General Virology
Volume	88
Issue number	11
DOIs	https://doi.org/10.1099/vir.0.83042-0
State	Published - Nov 2007

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Virology

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10.1099/vir.0.83042-0

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abstract = "Classical swine fever virus (CSFV)-macrophage interactions during infection were analysed by examining macrophage transcriptional responses via microarray. Eleven genes had increased mRNA levels (>2.5-fold, P<0.05) in infected cell cultures, including arginase-1, an inhibitor of nitric oxide production, phosphoinositide 3-kinase, chemokine receptor 4 and interleukin-1β. Lower levels of nitric oxide and increased arginase activity were found in CSFV-infected macrophages. These changes in gene expression in macrophages suggest viral modulation of host expression to suppress nitric oxide production.",

author = "Zaffuto, {K. M.} and Piccone, {M. E.} and Burrage, {T. G.} and Balinsky, {C. A.} and Risatti, {G. R.} and Borca, {M. V.} and Holinka, {L. G.} and Rock, {D. L.} and Afonso, {Claudio L.}",

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AU - Zaffuto, K. M.

AU - Piccone, M. E.

AU - Burrage, T. G.

AU - Balinsky, C. A.

AU - Risatti, G. R.

AU - Borca, M. V.

AU - Holinka, L. G.

AU - Rock, D. L.

AU - Afonso, Claudio L.

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AB - Classical swine fever virus (CSFV)-macrophage interactions during infection were analysed by examining macrophage transcriptional responses via microarray. Eleven genes had increased mRNA levels (>2.5-fold, P<0.05) in infected cell cultures, including arginase-1, an inhibitor of nitric oxide production, phosphoinositide 3-kinase, chemokine receptor 4 and interleukin-1β. Lower levels of nitric oxide and increased arginase activity were found in CSFV-infected macrophages. These changes in gene expression in macrophages suggest viral modulation of host expression to suppress nitric oxide production.

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Classical swine fever virus inhibits nitric oxide production in infected macrophages

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