Classic perspectives - electron transfer: Cupredoxins

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The cytochromes are ubiquitous heme proteins (>75,000 known)1 that play essential roles in biological electron transfer. They were originally classified on the basis of optical absorbance maxima characteristic of their prosthetic heme groups.2,3 The chemical structures of the most common biological hemes are shown in Fig. 1. Several classes of biological metal-chelating ligands, macrocyclic tetrapyrroles, include the porphyrins (22pe- ligands in hemes a, b, and c), chlorins (20pe- ligands in heme d), isobacteriochlorins (18pe- ligands as in heme d1), and corrins (20pe- ligands). Heme b in b-type cytochromes is an iron protoporphyrin IX complex in which the iron atom is ligated to the four pyrrole nitrogen atoms. Hemes a and c are derivatives of heme b.

Original languageEnglish (US)
Title of host publicationComprehensive Coordination Chemistry III
Number of pages24
ISBN (Electronic)9780081026885
ISBN (Print)9780081026892
StatePublished - Jul 21 2021

ASJC Scopus subject areas

  • General Chemistry


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