Class I and II lantibiotics from geobacillus thermodenitrificans

Yuki Goto (Inventor), Neha Garg (Inventor), Wilfred (Willem) A van der Donk (Inventor), Weixin Tang (Inventor), Satish Nair (Inventor)

Research output: Patent

Abstract

The disclosure provides lantibiotics geobacillin I and geobacillin II from Geobacillus thermodenitrificans, compositions comprising the lantibiotics, and methods of use of the lantibiotics. Further disclosed are the sequences of lantibiotics geobacillin I and geobacillin I, and alternative structures of geobacillin I and geobacillin II comprising amino acid substitutions. Antimicrobial compositions comprising one or more isolated geobacillins and a pharmaceutically acceptable carrier, and methods of reducing reproduction of bacteria comprising administering to a subject a therapeutically effective amount of the antimicrobial composition are also provided.
Original languageEnglish (US)
U.S. patent number9326523
Filing date2/7/13
StatePublished - May 3 2016

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