TY - JOUR
T1 - Circulating Triglycerides and the Association of Triglycerides with Dietary Intake Are Altered by Alpha-2-Heremans-Schmid Glycoprotein Polymorphisms
AU - Robinson, Katie N.
AU - Vazquez-Vidal, Itzel
AU - Marques, Courtney
AU - Andrade, Flavia Cristina Drumond
AU - Aradillas-Garcia, Celia
AU - Teran-Garcia, Margarita
N1 - This study was funded by University of ?llinois at Urbana-Champaign Research Board grant 匃爃笃爃礃爀 (to F.C.?. Andrade), the Center for ?ealth and Aging (to F.C.?. Andrade), the ACES Office of Research F?RE grant (to ?. Teran-Garcia & A. Wiley), and the US?A National ?nstitute of Food and Agriculture, ?atch Projects 匀ఀLLU-笃砃稁甃猃琁 匀ఀLLU-笃礃猁甃砃稁 and 匀ఀLLU-礃笃Fu甁ndin甃g w球a礂s alstoo p ? rovTiedreadn b-Gya trhceia U).n iver-sidad Autónoma de San Luis Potosí, ?ormones Laboratory at the School of ?edicine, the Clinical Biochemistry Laboratory at the Chemical Sciences School, and the Autonomous University of San Luis Potosí University ?ealth Center under agreement support C 爃笁PF? 爃甃爃砃爃砀a di(lltaos C-G. Aarrcia). Furthermore, K.N. Robinson was supported by the National ?nstitute for Agriculture under the ?llinois Transdisciplinary Obesity Prevention Program grant ( 球爃猃爁爃瘃稃稃砂ఀ to the ivision of Nutritcieosn aatl tShceie Unniversity of llinois.
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Background: Circulating fetuin-A (FetA) inhibits insulin receptor signaling and activates the toll-like receptor 4 proinflammatory cascade; thus, it may contribute to metabolic syndrome. Polymorphisms in alpha-2-Heremans-Schmid glycoprotein (AHSG), the gene which codes FetA, may influence metabolic syndrome progression in higher-risk ethnic groups. We aimed to identify whether individual variation in AHSG influences biomarkers of metabolic disease and obesity in young Mexican adults. Methods: The participants were Mexican college applicants (18-25 years, n = 641). Dietary intake, anthropometric data, and blood for the analysis of biomarkers and genetics were collected. Single nucleotide polymorphisms (SNPs) in AHSG (rs2518136 and rs4917) were genotyped. Results: Neither AHSG SNP was associated with body mass index (BMI) or waist circumference. rs4917 C allele carriers had lower triglycerides (TG) than T allele homozygotes (98.85 ± 2.3 vs. 112.2 ± 5.2 mg/dL, p = 0.0113). BMI was strongly associated with TG (p < 0.0001) regardless of genotype. The relationship between circulating TG and dietary intake of carbohydrates and saturated fat was significant in rs4917 CT allele heterozygotes only (p = 0.03 and p = 0.02, respectively). Conclusions: rs4917 T allele carriers had higher TG. This relationship was exaggerated in individuals with overweight and obesity. Dietary intake was significantly associated with TG in only those with heterozygosity at rs4917, suggesting that these individuals may be more susceptible to dietary interventions.
AB - Background: Circulating fetuin-A (FetA) inhibits insulin receptor signaling and activates the toll-like receptor 4 proinflammatory cascade; thus, it may contribute to metabolic syndrome. Polymorphisms in alpha-2-Heremans-Schmid glycoprotein (AHSG), the gene which codes FetA, may influence metabolic syndrome progression in higher-risk ethnic groups. We aimed to identify whether individual variation in AHSG influences biomarkers of metabolic disease and obesity in young Mexican adults. Methods: The participants were Mexican college applicants (18-25 years, n = 641). Dietary intake, anthropometric data, and blood for the analysis of biomarkers and genetics were collected. Single nucleotide polymorphisms (SNPs) in AHSG (rs2518136 and rs4917) were genotyped. Results: Neither AHSG SNP was associated with body mass index (BMI) or waist circumference. rs4917 C allele carriers had lower triglycerides (TG) than T allele homozygotes (98.85 ± 2.3 vs. 112.2 ± 5.2 mg/dL, p = 0.0113). BMI was strongly associated with TG (p < 0.0001) regardless of genotype. The relationship between circulating TG and dietary intake of carbohydrates and saturated fat was significant in rs4917 CT allele heterozygotes only (p = 0.03 and p = 0.02, respectively). Conclusions: rs4917 T allele carriers had higher TG. This relationship was exaggerated in individuals with overweight and obesity. Dietary intake was significantly associated with TG in only those with heterozygosity at rs4917, suggesting that these individuals may be more susceptible to dietary interventions.
KW - Fetuin-A
KW - Hispanics
KW - Metabolic syndrome
KW - Triglycerides
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U2 - 10.1159/000478657
DO - 10.1159/000478657
M3 - Article
C2 - 28858873
AN - SCOPUS:85028767916
SN - 1661-6499
VL - 10
SP - 75
EP - 83
JO - Journal of Nutrigenetics and Nutrigenomics
JF - Journal of Nutrigenetics and Nutrigenomics
IS - 3-4
ER -