Circular logic: Nonribosomal peptide-like macrocyclization with a ribosomal peptide catalyst

John A. McIntosh; Charles R. Robertson; Vinayak Agarwal; Satish K. Nair; Grzegorz W. Bulaj; Eric W. Schmidt

doi:10.1021/ja1067806

Circular logic: Nonribosomal peptide-like macrocyclization with a ribosomal peptide catalyst

John A. McIntosh, Charles R. Robertson, Vinayak Agarwal, Satish K. Nair, Grzegorz W. Bulaj, Eric W. Schmidt

Research output: Contribution to journal › Article › peer-review

Abstract

A protease from ribosomal peptide biosynthesis macrocyclizes diverse substrates, including those resembling nonribosomal peptide and hybrid polyketide-peptide products. The proposed mechanism is analogous to thioesterase-catalyzed chemistry, but the substrates are amide bonds rather than thioesters.

Original language	English (US)
Pages (from-to)	15499-15501
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	132
Issue number	44
DOIs	https://doi.org/10.1021/ja1067806
State	Published - Nov 10 2010

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja1067806

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abstract = "A protease from ribosomal peptide biosynthesis macrocyclizes diverse substrates, including those resembling nonribosomal peptide and hybrid polyketide-peptide products. The proposed mechanism is analogous to thioesterase-catalyzed chemistry, but the substrates are amide bonds rather than thioesters.",

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AU - Bulaj, Grzegorz W.

AU - Schmidt, Eric W.

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Circular logic: Nonribosomal peptide-like macrocyclization with a ribosomal peptide catalyst

Abstract

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