Circular logic: Nonribosomal peptide-like macrocyclization with a ribosomal peptide catalyst

John A. McIntosh, Charles R. Robertson, Vinayak Agarwal, Satish K. Nair, Grzegorz W. Bulaj, Eric W. Schmidt

Research output: Contribution to journalArticlepeer-review

Abstract

A protease from ribosomal peptide biosynthesis macrocyclizes diverse substrates, including those resembling nonribosomal peptide and hybrid polyketide-peptide products. The proposed mechanism is analogous to thioesterase-catalyzed chemistry, but the substrates are amide bonds rather than thioesters.

Original languageEnglish (US)
Pages (from-to)15499-15501
Number of pages3
JournalJournal of the American Chemical Society
Volume132
Issue number44
DOIs
StatePublished - Nov 10 2010

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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