Circadian rhythm of redox state regulates excitability in suprachiasmatic nucleus neurons

Tongfei A. Wang, Yanxun V. Yu, Gubbi Govindaiah, Xiaoying Ye, Liana Artinian, Todd P. Coleman, Jonathan V. Sweedler, Charles L. Cox, Martha U. Gillette

Research output: Contribution to journalArticlepeer-review


Daily rhythms of mammalian physiology, metabolism, and behavior parallel the day-night cycle. They are orchestrated by a central circadian clock in the brain, the suprachiasmatic nucleus (SCN). Transcription of clock genes is sensitive to metabolic changes in reduction and oxidation (redox); however, circadian cycles in protein oxidation have been reported in anucleate cells, where no transcription occurs. We investigated whether the SCN also expresses redox cycles and how such metabolic oscillations might affect neuronal physiology. We detected self-sustained circadian rhythms of SCN redox state that required the molecular clockwork. The redox oscillation could determine the excitability of SCN neurons through nontranscriptional modulation of multiple potassium (K +) channels. Thus, dynamic regulation of SCN excitability appears to be closely tied to metabolism that engages the clockwork machinery.

Original languageEnglish (US)
Pages (from-to)839-842
Number of pages4
Issue number6096
StatePublished - Aug 17 2012

ASJC Scopus subject areas

  • General


Dive into the research topics of 'Circadian rhythm of redox state regulates excitability in suprachiasmatic nucleus neurons'. Together they form a unique fingerprint.

Cite this