Abstract

Circadian rhythms in mammals are orchestrated by a central clock in the suprachiasmatic nucleus (SCN). The clock emerges from cell-autonomous processes. Clock proteins cause the rhythmic expression of clock genes as well as output genes. Structural features and posttranslational modifications of clock proteins determine their intermolecular associations, subcellular localization, transcriptional activity, and stability. Some clock proteins positively and negatively regulate their own rhythmic expression via feedback on transcription. Patterns of clock gene expression within SCN cells and tissue are complex. The understanding of mammalian clock mechanisms critical to timekeeping is as yet incomplete.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages901-908
Number of pages8
ISBN (Print)9780080450469
DOIs
StatePublished - Jan 1 2009

Fingerprint

Suprachiasmatic Nucleus
Gene Expression
Proteins
Post Translational Protein Processing
Circadian Rhythm
Mammals
Genes

Keywords

  • Alternative splicing
  • Behavior
  • Circadian
  • Clock gene
  • Clockwork
  • DNA-binding
  • Drosophila
  • Feedback loop
  • Genomic
  • Kinase
  • Light
  • Mammal
  • Mouse
  • Nuclear entry
  • Oscillator
  • Phase shift
  • Phosphorylation
  • Posttranslational modification (PTM)
  • Suprachiasmatic nucleus (SCN)
  • Transcription factor

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Gillette, M. L., & Tyan, S. H. (2009). Circadian Gene Expression in the Suprachiasmatic Nucleus. In Encyclopedia of Neuroscience (pp. 901-908). Elsevier Ltd. https://doi.org/10.1016/B978-008045046-9.01596-5

Circadian Gene Expression in the Suprachiasmatic Nucleus. / Gillette, Martha L; Tyan, S. H.

Encyclopedia of Neuroscience. Elsevier Ltd, 2009. p. 901-908.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gillette, ML & Tyan, SH 2009, Circadian Gene Expression in the Suprachiasmatic Nucleus. in Encyclopedia of Neuroscience. Elsevier Ltd, pp. 901-908. https://doi.org/10.1016/B978-008045046-9.01596-5
Gillette ML, Tyan SH. Circadian Gene Expression in the Suprachiasmatic Nucleus. In Encyclopedia of Neuroscience. Elsevier Ltd. 2009. p. 901-908 https://doi.org/10.1016/B978-008045046-9.01596-5
Gillette, Martha L ; Tyan, S. H. / Circadian Gene Expression in the Suprachiasmatic Nucleus. Encyclopedia of Neuroscience. Elsevier Ltd, 2009. pp. 901-908
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