Abstract

Circadian rhythms in mammals are orchestrated by a central clock in the suprachiasmatic nucleus (SCN). The clock emerges from cell-autonomous processes. Clock proteins cause the rhythmic expression of clock genes as well as output genes. Structural features and posttranslational modifications of clock proteins determine their intermolecular associations, subcellular localization, transcriptional activity, and stability. Some clock proteins positively and negatively regulate their own rhythmic expression via feedback on transcription. Patterns of clock gene expression within SCN cells and tissue are complex. The understanding of mammalian clock mechanisms critical to timekeeping is as yet incomplete.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages901-908
Number of pages8
ISBN (Print)9780080450469
DOIs
StatePublished - Jan 1 2009

Keywords

  • Alternative splicing
  • Behavior
  • Circadian
  • Clock gene
  • Clockwork
  • DNA-binding
  • Drosophila
  • Feedback loop
  • Genomic
  • Kinase
  • Light
  • Mammal
  • Mouse
  • Nuclear entry
  • Oscillator
  • Phase shift
  • Phosphorylation
  • Posttranslational modification (PTM)
  • Suprachiasmatic nucleus (SCN)
  • Transcription factor

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Circadian Gene Expression in the Suprachiasmatic Nucleus'. Together they form a unique fingerprint.

  • Cite this

    Gillette, M. U., & Tyan, S. H. (2009). Circadian Gene Expression in the Suprachiasmatic Nucleus. In Encyclopedia of Neuroscience (pp. 901-908). Elsevier Ltd. https://doi.org/10.1016/B978-008045046-9.01596-5