Abstract

Brain plasticity, the ability of the nervous system to encode experience, is a modulatory process leading to long-lasting structural and functional changes. Salient experiences induce plastic changes in neurons of the hippocampus, the basis of memory formation and recall. In the suprachiasmatic nucleus (SCN), the central circadian (∼24-h) clock, experience with light at night induces changes in neuronal state, leading to circadian plasticity. The SCN’s endogenous ∼24-h time-generator comprises a dynamic series of functional states, which gate plastic responses. This restricts light-induced alteration in SCN state-dynamics and outputs to the nighttime. Endogenously generated circadian oscillators coordinate the cyclic states of excitability and intracellular signaling molecules that prime SCN receptivity to plasticity signals, generating nightly windows of susceptibility. We propose that this constitutes a paradigm of ∼24-h iterative metaplasticity, the repeated, patterned occurrence of susceptibility to induction of neuronal plasticity. We detail effectors permissive for the cyclic susceptibility to plasticity. We consider similarities of intracellular and membrane mechanisms underlying plasticity in SCN circadian plasticity and in hippocampal long-term potentiation (LTP). The emerging prominence of the hippocampal circadian clock points to iterative metaplasticity in that tissue as well. Exploring these links holds great promise for understanding circadian shaping of synaptic plasticity, learning, and memory.

Original languageEnglish (US)
JournalFrontiers in Systems Neuroscience
Volume8
DOIs
StatePublished - Sep 19 2014

Fingerprint

Suprachiasmatic Nucleus
Neuronal Plasticity
Light
Intracellular Membranes
Circadian Clocks
Aptitude
Long-Term Potentiation
Nervous System
Plastics
Hippocampus
Learning
Neurons
Brain

Keywords

  • Circadian rhythms
  • Gating
  • Glutamatergic
  • Hippocampus
  • Iterative metaplasticity
  • Plasticity
  • Signaling
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience
  • Developmental Neuroscience

Cite this

Circadian gating of neuronal functionality : A basis for iterative metaplasticity. / Iyer, Rajashekar; Wang, Tongfei A.; Gillette, Martha U.

In: Frontiers in Systems Neuroscience, Vol. 8, 19.09.2014.

Research output: Contribution to journalReview article

@article{c6bd567c9e9c40d5a532cc68994a1cff,
title = "Circadian gating of neuronal functionality: A basis for iterative metaplasticity",
abstract = "Brain plasticity, the ability of the nervous system to encode experience, is a modulatory process leading to long-lasting structural and functional changes. Salient experiences induce plastic changes in neurons of the hippocampus, the basis of memory formation and recall. In the suprachiasmatic nucleus (SCN), the central circadian (∼24-h) clock, experience with light at night induces changes in neuronal state, leading to circadian plasticity. The SCN’s endogenous ∼24-h time-generator comprises a dynamic series of functional states, which gate plastic responses. This restricts light-induced alteration in SCN state-dynamics and outputs to the nighttime. Endogenously generated circadian oscillators coordinate the cyclic states of excitability and intracellular signaling molecules that prime SCN receptivity to plasticity signals, generating nightly windows of susceptibility. We propose that this constitutes a paradigm of ∼24-h iterative metaplasticity, the repeated, patterned occurrence of susceptibility to induction of neuronal plasticity. We detail effectors permissive for the cyclic susceptibility to plasticity. We consider similarities of intracellular and membrane mechanisms underlying plasticity in SCN circadian plasticity and in hippocampal long-term potentiation (LTP). The emerging prominence of the hippocampal circadian clock points to iterative metaplasticity in that tissue as well. Exploring these links holds great promise for understanding circadian shaping of synaptic plasticity, learning, and memory.",
keywords = "Circadian rhythms, Gating, Glutamatergic, Hippocampus, Iterative metaplasticity, Plasticity, Signaling, Suprachiasmatic nucleus",
author = "Rajashekar Iyer and Wang, {Tongfei A.} and Gillette, {Martha U.}",
year = "2014",
month = "9",
day = "19",
doi = "10.3389/fnsys.2014.00164",
language = "English (US)",
volume = "8",
journal = "Frontiers in Systems Neuroscience",
issn = "1662-5137",
publisher = "Frontiers Research Foundation",

}

TY - JOUR

T1 - Circadian gating of neuronal functionality

T2 - A basis for iterative metaplasticity

AU - Iyer, Rajashekar

AU - Wang, Tongfei A.

AU - Gillette, Martha U.

PY - 2014/9/19

Y1 - 2014/9/19

N2 - Brain plasticity, the ability of the nervous system to encode experience, is a modulatory process leading to long-lasting structural and functional changes. Salient experiences induce plastic changes in neurons of the hippocampus, the basis of memory formation and recall. In the suprachiasmatic nucleus (SCN), the central circadian (∼24-h) clock, experience with light at night induces changes in neuronal state, leading to circadian plasticity. The SCN’s endogenous ∼24-h time-generator comprises a dynamic series of functional states, which gate plastic responses. This restricts light-induced alteration in SCN state-dynamics and outputs to the nighttime. Endogenously generated circadian oscillators coordinate the cyclic states of excitability and intracellular signaling molecules that prime SCN receptivity to plasticity signals, generating nightly windows of susceptibility. We propose that this constitutes a paradigm of ∼24-h iterative metaplasticity, the repeated, patterned occurrence of susceptibility to induction of neuronal plasticity. We detail effectors permissive for the cyclic susceptibility to plasticity. We consider similarities of intracellular and membrane mechanisms underlying plasticity in SCN circadian plasticity and in hippocampal long-term potentiation (LTP). The emerging prominence of the hippocampal circadian clock points to iterative metaplasticity in that tissue as well. Exploring these links holds great promise for understanding circadian shaping of synaptic plasticity, learning, and memory.

AB - Brain plasticity, the ability of the nervous system to encode experience, is a modulatory process leading to long-lasting structural and functional changes. Salient experiences induce plastic changes in neurons of the hippocampus, the basis of memory formation and recall. In the suprachiasmatic nucleus (SCN), the central circadian (∼24-h) clock, experience with light at night induces changes in neuronal state, leading to circadian plasticity. The SCN’s endogenous ∼24-h time-generator comprises a dynamic series of functional states, which gate plastic responses. This restricts light-induced alteration in SCN state-dynamics and outputs to the nighttime. Endogenously generated circadian oscillators coordinate the cyclic states of excitability and intracellular signaling molecules that prime SCN receptivity to plasticity signals, generating nightly windows of susceptibility. We propose that this constitutes a paradigm of ∼24-h iterative metaplasticity, the repeated, patterned occurrence of susceptibility to induction of neuronal plasticity. We detail effectors permissive for the cyclic susceptibility to plasticity. We consider similarities of intracellular and membrane mechanisms underlying plasticity in SCN circadian plasticity and in hippocampal long-term potentiation (LTP). The emerging prominence of the hippocampal circadian clock points to iterative metaplasticity in that tissue as well. Exploring these links holds great promise for understanding circadian shaping of synaptic plasticity, learning, and memory.

KW - Circadian rhythms

KW - Gating

KW - Glutamatergic

KW - Hippocampus

KW - Iterative metaplasticity

KW - Plasticity

KW - Signaling

KW - Suprachiasmatic nucleus

UR - http://www.scopus.com/inward/record.url?scp=84907289316&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84907289316&partnerID=8YFLogxK

U2 - 10.3389/fnsys.2014.00164

DO - 10.3389/fnsys.2014.00164

M3 - Review article

AN - SCOPUS:84907289316

VL - 8

JO - Frontiers in Systems Neuroscience

JF - Frontiers in Systems Neuroscience

SN - 1662-5137

ER -