Cigarette smoking and preeclampsia

Hillary Klonoff-Cohen, Sharon Edelstein, David Savitz

Research output: Contribution to journalArticlepeer-review


Objective: To examine the relationship between cigarette smoking during pregnancy and the development of preeclampsia. Methods: A case-control study compared the smoking histories of 110 nulliparous preeclamptic women and 115 healthy nulliparas aged 15-35 years who delivered at North Carolina Memorial Hospital. Results: Unconditional logistic regression relating smoking during pregnancy to preeclampsia yielded an odds ratio of 0.71 (95% confidence interval 0.33-1.50) when adjusting for working during pregnancy, alcohol use, medication use, contraceptive choices with the father of the index pregnancy, and family history of preeclampsia. There was no evidence of a dose-response effect of reduced risk for heavier smokers. Conclusions: Despite major methodologic improvements from previous studies, including rigorous diagnostic criteria for preeclampsia, a negative, non-statistically significant association persisted between cigarette smoking during pregnancy and preeclampsia, similar in magnitude to that of previous reports.

Original languageEnglish (US)
Pages (from-to)541-544
Number of pages4
JournalObstetrics and Gynecology
Issue number4
StatePublished - Apr 1993
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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