Chronopharmacokinetics of theophylline in the cat

J. A. DYE, B. C. McKIERNAN, C. A. NEFF‐DAVIS, G. D. KORITZ

Research output: Contribution to journalArticle

Abstract

Dye, J.A., McKiernan, B.C., Neff‐Davis, C.A. & Koritz, G.D. Chronopharmacokinetics of theophylline in the cat. J. vet. Pharmacol. Therap. 13, 278–286. Studies of theophylline pharmacokinetics in humans have shown that a higher peak concentration and area under the curve AUC, with a shorter time to peak (tp) occur after a morning dose than after an evening dose. The purpose of this study was to determine whether theophylline pharmacokinetics in the cat were also influenced by the administration time of day. Theophylline was administered to six cats in a three‐way cross‐over study as a single dose of intravenous aminophylline and oral sustained‐release theophylline (Slo‐bid Gyrocapsr̀ and Theo‐Durr̀ Tablets), between 08.00–09.00 h (Phase I) and 20.00–21.00 h (Phase II). Subjects were maintained on a 12‐h light (08.00–20.00 h):12‐h dark cycle. Similar to the human studies, the tp was shorter following the morning dose. Conversely, however, the peak plasma theophylline concentrations achieved in these cats following intravenous aminophylline and oral Slo‐bidr̀ were significantly higher following the evening dose. The AUC obtained for Theo‐Durr̀ was also significantly greater following the evening dose. No single pharmacokinetic parameter could account for the higher plasma concentrations achieved following the evening dose. J. A. Dye, Department of Veterinary Clinical Medicine, University of Illinois, Urbana, IL 61801, USA.

Original languageEnglish (US)
Pages (from-to)278-286
Number of pages9
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume13
Issue number3
DOIs
StatePublished - Sep 1990

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

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