Chronic social stress impairs virus specific adaptive immunity during acute Theiler's virus infection

Erin E. Young; Elisabeth G. Vichaya; Nicole M. Reusser; Jennifer L. Cook; Andrew J. Steelman; C. Jane R. Welsh; Mary W. Meagher

doi:10.1016/j.jneuroim.2012.08.014

Chronic social stress impairs virus specific adaptive immunity during acute Theiler's virus infection

Erin E. Young, Elisabeth G. Vichaya, Nicole M. Reusser, Jennifer L. Cook, Andrew J. Steelman, C. Jane R. Welsh, Mary W. Meagher

Research output: Contribution to journal › Article › peer-review

Abstract

Prior exposure to social disruption (SDR) stress exacerbates Theiler's murine encephalomyelitis virus (TMEV) infection, a model of multiple sclerosis. Here we examined the impact of SDR on T cell responses to TMEV infection in SJL mice. SDR impaired viral clearance and exacerbated acute disease. Moreover, TMEV infection alone increased CD4 and CD8 mRNA expression in brain and spleen while SDR impaired this response. SDR decreased both CD4⁺ and CD8⁺ virus-specific T cells in CNS, but not spleen. These findings suggest that SDR-induced suppression of virus-specific T cell responses contributes to impairments in viral clearance and exacerbation of acute disease.

Original language	English (US)
Pages (from-to)	19-27
Number of pages	9
Journal	Journal of Neuroimmunology
Volume	254
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2012.08.014
State	Published - Jan 15 2013
Externally published	Yes

Keywords

Adaptive immune response
Multiple sclerosis
Social stress
T cell
TMEV
Theiler's murine encephalomyelitis virus

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

Online availability

10.1016/j.jneuroim.2012.08.014

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title = "Chronic social stress impairs virus specific adaptive immunity during acute Theiler's virus infection",

abstract = "Prior exposure to social disruption (SDR) stress exacerbates Theiler's murine encephalomyelitis virus (TMEV) infection, a model of multiple sclerosis. Here we examined the impact of SDR on T cell responses to TMEV infection in SJL mice. SDR impaired viral clearance and exacerbated acute disease. Moreover, TMEV infection alone increased CD4 and CD8 mRNA expression in brain and spleen while SDR impaired this response. SDR decreased both CD4+ and CD8+ virus-specific T cells in CNS, but not spleen. These findings suggest that SDR-induced suppression of virus-specific T cell responses contributes to impairments in viral clearance and exacerbation of acute disease.",

keywords = "Adaptive immune response, Multiple sclerosis, Social stress, T cell, TMEV, Theiler's murine encephalomyelitis virus",

author = "Young, {Erin E.} and Vichaya, {Elisabeth G.} and Reusser, {Nicole M.} and Cook, {Jennifer L.} and Steelman, {Andrew J.} and Welsh, {C. Jane R.} and Meagher, {Mary W.}",

note = "Funding Information: This research was supported by NIH/NINDS R01-NS060822 awarded to MWM and CJW. The authors would like to thank Dr. Colin Young, Department of Veterinary Integrative Biosciences Texas A&M University, for his technical expertise and assistance. In addition, we would like to thank Kristen Montgomery and Adriana Mariscal for their work on behavioral data collection. Dr. Erin E. Young is now a Research Assistant Professor in the Department of Anesthesiology, University of Pittsburgh School of Medicine (Pittsburgh, PA). Dr. Elisabeth G. Vichaya is currently a Postdoctoral fellow in the Department of Symptoms Research at MD Anderson Cancer Center (Houston, TX).",

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AU - Reusser, Nicole M.

AU - Cook, Jennifer L.

AU - Steelman, Andrew J.

AU - Welsh, C. Jane R.

AU - Meagher, Mary W.

N1 - Funding Information: This research was supported by NIH/NINDS R01-NS060822 awarded to MWM and CJW. The authors would like to thank Dr. Colin Young, Department of Veterinary Integrative Biosciences Texas A&M University, for his technical expertise and assistance. In addition, we would like to thank Kristen Montgomery and Adriana Mariscal for their work on behavioral data collection. Dr. Erin E. Young is now a Research Assistant Professor in the Department of Anesthesiology, University of Pittsburgh School of Medicine (Pittsburgh, PA). Dr. Elisabeth G. Vichaya is currently a Postdoctoral fellow in the Department of Symptoms Research at MD Anderson Cancer Center (Houston, TX).

PY - 2013/1/15

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Chronic social stress impairs virus specific adaptive immunity during acute Theiler's virus infection

Abstract

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